INTRODUÇÃO: No Módulo de Biologia Celular e Molecular no 1º período de medicina é idealizada atividade prática de extração do DNA utilizando a banana e materiais domésticos. Tal atividade é ministrada pelos monitores explicando cada etapa do experimento. OBJETIVO: O objetivo é entender e desmitificar as técnicas moleculares usadas na rotina médica. MÉTODO: Os alunos da turma de 2016.1 e 2016.2 foram distribuído...
Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2017-06-05T16:30:20Z No. of bitstreams: 1 14_v.9_2.pdf: 221781 bytes, checksum: d402fed1f78e9ac81bb6a9c54c8a794e (MD5); Made available in DSpace on 2017-06-05T16:30:20Z (GMT). No. of bitstreams: 1 14_v.9_2.pdf: 221781 bytes, checksum: d402fed1f78e9ac81bb6a9c54c8a794e (MD5) Previous issue date: 2010-05; O Vírus Esptein-Barr (EBV) é amplamente...
Background: The distribution of mitochondrial DNA (mtDNA) lineages in Brazil is heterogeneous due to different regional colonization dynamics. Northeastern Brazil, although being an important region in terms of human imigration and ethnic admixture, has little information regarding its population mtDNA composition. Here, we determine which mitochondrial lineages contributed to the formation of the Northeastern ...
SUMMARY: We evaluated interleukin-10 ( IL10 ) - 592 C / A, IL4 - 589 C / T, interferon gamma ( IFNG ) + 874 A / T, cytotoxic T-lymphocyte-associated antigen 4 ( CTLA4 ) + 49 A / G gene polymorphisms associated with efavirenz hypersensitivity reaction. A total of 63 human immunodeficiency virus-positive patients under treatment at a public hospital were included in the study, of whom 21 presented with efavirenz ...
Our aim was to evaluate genetic polymorphism of molecules involved in immunoregulatory/allergic processes in patients who presented with cutaneous hypersensitivity caused by chemically unrelated nonsteroidal anti-inflammatory drugs. Polymorphisms at IL10 (–1082 G>A), IL4 (–589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases and 97 controls by the polymerase chain reaction-restriction fr...
SNPs have been associated with gastric cancer susceptibility. Thus, we evaluated the influence of SNPs in DNA repair genes APE1 2197(T>G) and MLH1 -93(G>A), as well as in CDH1 at positions -160 (C>A) and -347 (G>GA) in gastric cancer risk. Analyses were performed on 264 GC patients and 391 healthy controls matched by age and sex from two regions in Brazil, Ceará and Pará. In the general analysis, a protective w...
Background Gastric cancer results from a multifactorial process and is one of the most common causes of death worldwide. These tumors can arise in the distal stomach (non-cardia) and in the cardia region, presenting different characteristics and frequency of occurrence worldwide. Aims To search for differences between tumors of dif- ferent locations that could explain the presence of cardia tumors, considering ...
Universidade Federal do Par?. Hospital Universit?rio Jo?o de Barros Barreto. Departamento de Anatomia Patol?gica. Bel?m, PA, Brasil.; Universidade Federal de S?o Paulo. Departamento de Morfologia e Gen?tica. Disciplina de Gen?tica. S?o Paulo, SP. Brasil.; Universidade Federal do Par?. Hospital Universit?rio Jo?o de Barros Barreto. Departamento de Anatomia Patol?gica. Bel?m, PA, Brasil.; Universidade Federal do ...
Objectives: To better understand the etiologic factors that can influence preeclampsia, we investigated hereditary factors for thrombosis, FV Leiden, F II 20210A mutation and the polymorphism C677T of the MTHFR, as singly and as in association, in a group of women from Ceará state- Northeast Brazil with severe preeclampsia. Material and Methods: We conducted a case-control study. 101 cases of severe preeclampsi...
The human papillomavirus (HPV) is an epitheliotropic agent whose high-risk genotypes have a well-established link with the development of cervical cancer. Although the relation of HPV to the oral squamous cell carcinoma (OSCC) has been studied since the beginning of the 1980s, its role in the oral carcinogenesis and the probable underlying molecular mechanisms are still not fully elucidated. We performed a syst...