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Unmoving and uninflamed: characterizing neuroinflammatory dysfunction in the Wi...

Farinha Ferreira, Jorge Miguel; Magalhães, Daniela M; Neuparth-Sottomayor, Mariana; Rafael, H.; Miranda-Lourenço, Catarina; Sebastião, Ana M

Reductionistic research on depressive disorders has been hampered by the limitations of animal models. Recently, it has been hypothesized that neuroinflammation is a key player in depressive disorders. The Wistar-Kyoto (WKY) rat is an often-used animal model of depression, but no information so far exists on its neuroinflammatory profile. As such, we compared male young adult WKY rats to Wistar (WS) controls, w...


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