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Synthesis of selenium-quinone hybrid compounds with potential antitumor activit...
Jardim, Guilherme A. M.; Cruz, Eduardo H. G. da; Valença, Wagner O.; Lima, Daisy J. B.; Cavalcanti, Bruno C.; Pessoa, Claudia; Rafique, JamalAbstract: In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), ...
Date: 2018
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Origin: Oasisbr