7 documents found, page 1 of 1

Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling

A robust and efficient cellular response to lysosomal membrane damage prevents leakage from the lysosome lumen into the cytoplasm. This response is understood to happen through either lysosomal membrane repair or lysophagy. Here we report exocytosis as a third response mechanism to lysosomal damage, which is further potentiated when membrane repair or lysosomal degradation mechanisms are impaired. We show that ...

Extracellular vesicles improve GABAergic transmission in Huntington's disease i...

Background: Extracellular vesicles (EVs) carry bioactive molecules associated with various biological processes, including miRNAs. In both Huntington’s disease (HD) models and human samples, altered expression of miRNAs involved in synapse regulation was reported. Recently, the use of EV cargo to reverse phenotypic alterations in disease models with synaptopathy as the end result of the pathophysiological casca...

Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegans

Exact mechanisms of heat shock-induced lifespan extension, although documented across species, are still not well understood. Here, we show that fully functional peroxisomes, specifically peroxisomal catalase, are needed for the activation of canonical heat shock response and heat-induced hormesis in Caenorhabditis elegans Although during heat shock, the HSP-70 chaperone is strongly up-regulated in the WT and i...

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondr...

Parkinson's Disease (PD) is a neurodegenerative disorder affecting more than 10 million people worldwide. Currently, PD has no cure and no early diagnostics methods exist. Mitochondrial dysfunction is presented in the early stages of PD, and it is considered an important pathophysiology component. We have previously developed mitochondria-targeted hydroxycinnamic acid derivatives, presenting antioxidant and iro...

Corrigendum to 'A mitochondria-targeted caffeic acid derivative reverts cellula...

Endophilin-A coordinates priming and fusion of neurosecretory vesicles via inte...

Endophilins-A are conserved endocytic adaptors with membrane curvature-sensing and -inducing properties. We show here that, independently of their role in endocytosis, endophilin-A1 and endophilin-A2 regulate exocytosis of neurosecretory vesicles. The number and distribution of neurosecretory vesicles were not changed in chromaffin cells lacking endophilin-A, yet fast capacitance and amperometry measurements re...

Executable graphics for PBNM

The specification of a policy is performed in a policy language, usually following a textual representation. However, humans process images faster than text and they are prepared to process information presented in two or more dimensions: sometimes it is easier to explain things using figures and their graphical relations than writing textual representations. This paper describes a visual language, in the form ...