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Extracellular DNA release acts as an antifungal resistance mechanism in mature ...
Rajendran, R.; Williams, C.; Lappin, D. F.; Millington, O.; Martins, Margarida Isabel Barros Coelho; Ramage, G.Aspergillus fumigatus has been shown to form biofilms that are associated with adaptive antifungal resistance mechanisms. These include multidrug efflux pumps, heat shock proteins, and extracellular matrix (ECM). ECM is a key structural and protective component of microbial biofilms and in bacteria has been shown to contain extracellular DNA (eDNA). We therefore hypothesized that A. fumigatus biofilms also poss...
Date: 2013
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Origin: RepositóriUM - Universidade do Minho