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Protecting Older Patients with Cardiovascular Diseases from COVID-19 Complicati...
Alves, M; Fernandes, M; Bahat, G; Benetos, A; Clemente, H; Grodzicki, T; Martínez-Sellés, M; Mattace-Raso, F; Rajkumar, C; Ungar, A; Werner, NPurpose: In the pathogenesis of severe COVID-19 complications, derangements of renin-angiotensin-aldosterone system (RAAS), vascular endothelial dysfunction leading to inflammation and coagulopathy, and arrhythmias play an important role. Therefore, it is worth considering the use of currently available drugs to protect COVID-19 patients with cardiovascular diseases. Methods: We review the current experience of...
Current Evidence on the Impact of Medication Optimization or Pharmacological In...
Pazan, F; Petrovic, M; Cherubini, A; Onder, G; Cruz-Jentoft, A; Denkinger, M; van der Cammen, T; Stevenson, J; Ibrahim, K; Rajkumar, C; Bakken, MBackground: Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty. Methods: A literature search was performed in Medline to detect prospective randomized controlled trials (RCTs) testing the effects of pharmacological interventions or medication optimiza...