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An evolutionary NS1 mutation enhances Zika virus evasion of host interferon ind...
Xia, Hongjie; Luo, Huanle; Shan, Chao; Muruato, Antonio E; Nunes, Bruno Tardelli Diniz; Medeiros, Daniele Barbosa de Almeida; Zou, Jing; Xie, XupingUniversity of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.; University of Texas Medical Branch. Department of Microbiology & Immunology. Galveston, TX, USA.; University of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA.; University of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA / U...
TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial...
McNab, Finlay W.; Ewbank, John; Rajsbaum, Ricardo; Stavropoulos, Evangelos; Martirosyan, Anna; Redford, Paul S.; Wu, Xuemei; Graham, Christine M.Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading cause of mortality and morbidity worldwide, causing ~1.4 million deaths per year. Key immune components for host protection during tuberculosis include the cytokines IL-12, IL-1, and TNF-a, as well as IFN-? and CD4(+) Th1 cells. However, immune factors determining whether individuals control infection or progress to active tuberculosis are in...
Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, ...
Boonstra, André; Rajsbaum, Ricardo; Holman, Mary; Marques, Rute; Asselin-Paturel, Carine; Pereira, João Pedro; Bates, Elizabeth E. M.; Akira, ShizuoWe have previously reported that mouse plasmacytoid dendritic cells (DC) produce high levels of IL-12p70, whereas bone marrow-derived myeloid DC and splenic DC produce substantially lower levels of this cytokine when activated with the TLR-9 ligand CpG. We now show that in response to CpG stimulation, high levels of IL-10 are secreted by macrophages, intermediate levels by myeloid DC, but no detectable IL-10 is...