2 documents found, page 1 of 1
Procedimentos Operativos Normalizados para pesquisa de informação clínica sobre...
Abrantes, C.; Rama, A. C.; Caramona, M. M.; Meliço-Silvestre, A.; Fernandez-Llimos, F.; Figueiredo, I. V.Information related to adverse effects of antiretroviral therapy can determine non-compliance and future therapeutic options. Evidence based practice includes a focalized clinical question to obtain the better information assessed by the parameters sensitivity and specificity. The main purpose of the work is the optimization of a systematic methodology of research clinical information about adverse effects of a...
Evaluation of gastric toxicity of indomethacin acid, salt form and complexed fo...
Rama, A. C.; Figueiredo, Isabel Vitoria; Veiga, F.; Castel-Branco, M. M.; Cabrita, A. M. S.; Caramona, M. M.Indomethacin (IM) is a non-steroidal anti-inflammatory drug which inhibits prostaglandin biosynthesis. It is practically insoluble in water and has the capacity to induce gastric injury. Hydroxypropyl-b-cyclodextrin (HP-b-CD) is an alkylated derivative of b-CD with the capacity to form inclusion complexes with suitable molecules. IM is considered to form partial inclusion complexes with HP-b-CD by enclosure of ...