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Translational switch during integrated stress response: the examples of p53 and...
Lacerda, Rafaela; Pereira, Bruna; Menezes, Juliane; Ramos, Ana; Neves, Ana Rita; Candeias, Marco M; Romão, LuísaThe scanning model for eukaryotic mRNA translation initiation states that the small ribosomal subunit, along with initiation factors, binds to the cap structure at the 5’ end of the mRNA and scans the 5’ untranslated region (5’UTR) until an initiation codon is found. However, when cells are exposed to stress stimuli, cap-dependent translation is inhibited, while the synthesis of some proteins is maintained by a...
Data: 2020
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Origem: Repositório Científico do Instituto Nacional de Saúde