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Correction
Martins, Filipa; Arada, Renata; Barros, Hélio; Matos, Paulo; Ramalho, José; Ceña, Valentín; Bonifácio, Vasco D.B.; Gonçalves, Luís G.; Serpa, JacintaPublisher Copyright: © The Author(s) 2025.; Correction to: Cancer Gene Therapyhttps://doi.org/10.1038/s41417-025-00906-8, published online 27 April 2025 The article 'Lactate-coated polyurea-siRNA dendriplex: a gene therapy directed and metabolism-based strategy to impair glioblastoma (GBM)', written by Filipa Martins, Renata Arada, Hélio Barros, Paulo Matos, José Ramalho, Valentín Ceña, Vasco D. B. Bonifácio, L...
Rebuttal to the commentary on “Assessment of the Implementation of the Internat...
Queiroz, Guilherme; Maia, Joana; Gomes, Filipa; Chen-Xu, José; China, Joana; Pereira, Sofia Carmezim; Ferreira, Patrícia Pita; Ramalho, JoséFunding Information: GQ received a predoctoral fellowship from La Caixa INPhINIT; received support for attending meetings and/or travel from St Jude Children and Research Hospital and Associa\u00E7\u00E3o Portuguesa de Pais e Doentes com Hemoglo-binopatias. Funding Information: The original study was conducted as part of the Specialization Course in Public Health, offered by the National School of Public Health...
Performance of the ACMG-AMP criteria in a large familial renal glucosuria cohor...
Barata, Rui; Fila, Marc; Dalla-Vale, Fabienne; Bogarin, Roberto; Nunes, Paula; Ramalho, José; Rueff, Jose; Calado, JoaquimFunding Information: This work was supported by grant UID/BIM/00009/2016, Portuguese Science and Technology Foundation. Publisher Copyright: © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.; Familial Renal Glucosuria (FRG) is a co-dominantly inherited trait characterized by orthoglycaemic glucosuria. From 2003 to 2015 we have reported several cohorts validating SLC5A2 (16p11.2), encoding SGLT2 ...
Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lip...
Domingues, Neuza; Marques, André R.A.; Calado, Rita Diogo Almeida; Ferreira, Inês; Ramos, Cristiano; Ramalho, José; I. L. Soares, Maria; Pereira, TelmoFunding Information: This work was financially supported by FCT (Foundation for Science and Technology of the Portuguese Ministry of Science and Higher Education) through national funds and co‐funded by FEDER under the PT2020 Partnership (Ref. PTDC/MED‐PAT/29395/2017, 2022.01305.PTDC and 2022.03249.PTDC). The Coimbra Chemistry Center (CQC) is supported by the FCT through Project UID/QUI/00313/2019. MSCA‐RISE: “...
LAMP2A regulates the loading of proteins into exosomes
Ferreira, João Vasco; da Rosa Soares, Ana; Ramalho, José; Máximo Carvalho, Catarina; Cardoso, Maria Helena; Pintado, Petra; Carvalho, Ana SofiaExosomes are extracellular vesicles of endosomal origin that are released by practically all cell types across metazoans. Exosomes are active vehicles of intercellular communication and can transfer lipids, RNAs, and proteins between different cells, tissues, or organs. Here, we describe a mechanism whereby proteins containing a KFERQ motif pentapeptide are loaded into a subpopulation of exosomes in a process t...
A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC...
Catarino, Steve; Ribeiro-Rodrigues, Teresa M; Sá Ferreira, Rita; Ramalho, José; Abert, Christine; Martens, Sascha; Girão, HenriqueThis research was supported by the European Regional Development Fund (ERDF) through the Operational Program for Competitiveness Factors (COMPETE) [under the projects PAC “NETDIAMOND” POCI-01-0145-FEDER-016385; HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323; POCI-01-0145-FEDER-007440, CENTRO-01-0145-FEDER-032179, CENTRO-01-0145-FEDER-032414,FCTUID/NEU/04539/2013 and ID/NEU/04539/2019]. This research is base...