6 documents found, page 1 of 1
Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
Colón, David F.; Wanderley, Carlos W.; Franchin, Marcelo; Silva, Camila M.; Hiroki, Carlos H.; Castanheira, Fernanda V. S.; Donate, Paula B.Background: Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. Methods: Infant (2 weeks old) and adult (6 weeks old) mice were submitted to sepsis by intraperitoneal (i.p.) injection of bacteria suspension or lipopolysaccharide (LPS). Neutrophil infiltration, bacteremia, ...
Incidence, predictive factors and clinical significance of development of porta...
Ferreira, Carlos; Marinho, Rui; Cortez-Pinto, Helena; Ferreira, Paula; Dias, Margarida S.; Vasconcelos, Mariana; Alexandrino, Paula; Serejo, FátimaBackground and aims: The role of portal vein thrombosis (PVT) in the natural history of cirrhosis is controversial. There are few prospective studies validating risk factors for development of PVT. We analysed the incidence, factors associated with PVT development and its influence on cirrhosis decompensations and orthotopic liver transplant (OLT)-free survival. Methods: In this prospective observational study ...
Chronic liver disease staging classification based on ultrasound, clinical and ...
Ribeiro, Ricardo; Marinho, Rui; Velosa, José; Ramalho, Fernando; Sanches, JoãoIn this work the identification and diagnosis of various stages of chronic liver disease is addressed. The classification results of a support vector machine, a decision tree and a k-nearest neighbor classifier are compared. Ultrasound image intensity and textural features are jointly used with clinical and laboratorial data in the staging process. The classifiers training is performed by using a population of ...
Diffuse liver disease classification from ultrasound surface characterization, ...
Ribeiro, Ricardo; Marinho, Rui; Velosa, José; Ramalho, Fernando; Sanches, JoãoIn this work liver contour is semi-automatically segmented and quantified in order to help the identification and diagnosis of diffuse liver disease. The features extracted from the liver contour are jointly used with clinical and laboratorial data in the staging process. The classification results of a support vector machine, a Bayesian and a k-nearest neighbor classifier are compared. A population of 88 patie...
The usefulness of ultrasound in the classification of chronic liver disease
Ribeiro, Ricardo; Marinho, Rui; Velosa, José; Ramalho, Fernando; Sanches, João; Suri, J. S.Chronic Liver Disease is a progressive, most of the time asymptomatic, and potentially fatal disease. In this paper, a semi-automatic procedure to stage this disease is proposed based on ultrasound liver images, clinical and laboratorial data. In the core of the algorithm two classifiers are used: a k nearest neighbor and a Support Vector Machine, with different kernels. The classifiers were trained with the pr...
Hepatitis a: changes in the epidemiological pattern
Marinho, Rui Tato; Valente, Ana; Ramalho, Fernando; Moura., M. Carneiro DeIntroduction: There is evidence, that is corroborated by several other authors, pointing toward a change in the epidemiological patterns of hepatitis A in various European, American, and even Asian countries. Knowing the current prevalence of anti-hepatitis A virus (anti-HAV) antibodies is thus imperative, all the more so that the anti-hepatitis A vaccine has begun to be marketed in Portugal. Objective: To asse...