6 documents found, page 1 of 1
Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
Mendes, Gabriel; Santos, Maria Leonor; Ramalho, João Francisco; Duarte, Aida; Caneiras, CatiaHypervirulence and carbapenem-resistant have emerged as two distinct evolutionary pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing a great threat to public health. However, as the boundaries separating these two pathotypes fade, we assist a worrisome convergence in certain high-risk clones, causing hospital outbreaks and challenging every therapeutic option available. To...
Saúde ambiental : caderno de notas soltas III
Santos, Ricardo; Santos, Osvaldo; Abreu, Ana; Caminha, Luís; Costa, Andreia; Sul, Susana; Nogueira, Paulo Jorge; Henriques, Adriana; Arriaga, MiguelNa sua 3.ª edição, o Caderno de Notas Soltas pretende reunir diferentes perspetivas e metodologias, celebrando a sua razão de ser e a nobreza da sua génese intimamente ligada à realidade dos estudantes. Na verdade, passados três anos retomamos uma colaboração firmada desde a primeira hora com a Associação de Estudantes da Faculdade de Medicina de Lisboa (AEFML), num registo de proximidade da comunidade estudant...
Genomic characterisation of a novel KPC-98-producing clinical Klebsiella pneumo...
Mendes, Gabriel; Santos, Maria Leonor; Ramalho, João Francisco; Bruschy-Fonseca, Ana; Lito, Luís; Pedro, Diogo; Duarte, Aida; Cristino, José MeloCeftazidime/avibactam (CZA) is a novel drug that inactivates Ambler class A, including Klebsiella pneumoniae carbapenemases (KPC), class C and class D β-lactamases, but is not active against metallo-β-lactamases (class B). Despite its limited use worldwide, emerging cases of CZA-resistant isolates producing variants of the blaKPC gene have been reported. In this study, we report a novel KPC-98 variant conferrin...
First outbreak of NDM-1-producing Klebsiella pneumoniae ST11 in a Portuguese ho...
Mendes, Gabriel; Ramalho, João Francisco; Duarte, Aida; Pedrosa, Adriana; Silva, Ana Cristina; Méndez, Lucía; Caneiras, CatiaNew Delhi metallo-β-lactamase (NDM) carbapenemase has been considered a global threat due to its worldwide widespread in recent years. In Portugal, a very low number of infections with NDM-producing Enterobacterales has been reported. A total of 52 strains from 40 patients and 1 environmental sample isolated during COVID-19 pandemic were included in this study. Wholegenome sequencing (WGS) was performed on 20 c...
First description of Ceftazidime/Avibactam resistance in an ST13 KPC-70-produci...
Mendes, Gabriel; Ramalho, João Francisco; Bruschy-Fonseca, Ana; Lito, Luís; Duarte, Aida; Cristino, José Melo; Caneiras, CatiaThe combination of ceftazidime/avibactam (CZA) is a novel β-lactam/β-lactamase inhibitor with activity against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales. Emerging cases caused by CZA-resistant strains that produce variants of KPC genes have already been reported worldwide. However, to the best of our knowledge, no CZA-resistant strains were reported in Portugal. In September 2019, a K...
Whole-genome sequencing enables molecular characterization of non-clonal group ...
Mendes, Gabriel; Ramalho, João Francisco; Bruschy Fonseca, Ana; Lito, Luís; Duarte, Aida; Cristino, José Melo; Caneiras, CatiaThe carbapenem-resistant Enterobacterales (CRE) strains have been identified by the World Health Organization as critical priority pathogens in research and development of diagnostics, treatments, and vaccines. However, recent molecular information about carbapenem-resistant K. pneumoniae (CRK) epidemiology in Portugal is still scarce. Thus, this study aimed to provide the molecular epidemiology, resistome, and...