3 documents found, page 1 of 1
Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human N...
Ramalho,Suelem D.; Pinto,Meri Emili F.; Andricopulo,Renata K.; Sanches,Paulo R. S.; Silveira,Edilberto R.; Cilli,Eduardo M.; Andricopulo,Adriano D.Orbitides are a class of small naturally occurring cyclic peptides with structural and functional diversities. Their chemical properties make this class feasible to be obtained by solid phase peptide synthesis (SPPS). Therefore, this synthetic accessibility enables useful application and facilitates the identification of analogues, bioactivity studies, and thus, enables them to be applied to obtain peptide libr...
The Genus Psychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biol...
Calixto,Nivea O.; Pinto,Meri Emili F.; Ramalho,Suelem D.; Burger,Marcela C. M.; Bobey,Antonio F.; Young,Maria Claudia Marx; Bolzani,Vanderlan S.Psychotria genus (Rubiaceae) is featured into the angiosperm, being the most speciose genus comprising approximately 1600 species. The available references demonstrate that Psychotria has several uses on traditional medicine including spiritual and cultural purposes, and presents great potential on pharmacological properties, especially the one related to neurodegenerative diseases. Despite its wide biological ...
Leishmanicidal galloylquinic acids are noncompetitive inhibitors of arginase
Sousa,Lorena R. F. de; Ramalho,Suelem D.; Fernandes,João B.; Silva,Maria Fátima das G. F. da; Iemma,Mônica R. da C.; Corrêa,Caroindes J.Leishmanicidal galloylquinic acids were isolated from the ethyl acetate extract of Byrsonima coccolobifolia. These phenols and gallic acid showed to be a new class of potent noncompetitive inhibitors of arginase ARG (Ki ranging from 0.10 to 0.68 µmol L-1) from Leishmania amazonensis. Quinic acid did not exhibit significant inhibition of ARG, indicating that galloyl moiety has important features that allows the ...