2 documents found, page 1 of 1
Gene delivery using dendrimer/pDNA complexes immobilized in electrospun fibers ...
Ramalingam, Kirthiga; Castro, Rita; Pires, Pedro; Shi, Xiangyang; Rodrigues, João; Xiao, Shili; Tomás, HelenaA gene delivery platform for potential use in tissue engineering applications was developed by surface functionalization of biodegradable electrospun poly(lactic-co-glycolic acid) (PLGA) fibers with nanolayers of chitosan (cationic polymer) and alginate (anionic polymer) using the Layer-by-Layer (LbL) technique. The developed system not only supported the attachment and growth of human Mesenchymal Stem Cells (h...
Gene delivery using dendrimer/pDNA complexes immobilized in electrospun fibers ...
Ramalingam, KirthigaTissue engineering is an important branch of regenerative medicine that uses cells, materials (scaffolds), and suitable biochemical and physicochemical factors to improve or replace specific biological functions. In particular, the control of cell behavior (namely, of cell adhesion, proliferation and differentiation) is a key aspect for the design of successful therapeutical approaches. In this study, poly(lact...