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Insight into the efficiency of microalgae’ lipidic extracts as photosensitizers...

Mendonça, Inês; Silva, Daniela; Conde, Tiago; Maurício, Tatiana; Cardoso, Helena; Pereira, Hugo; Bartolomeu, Maria; Vieira, Cátia; Domingues, M. Rosário

Antibacterial resistance causes around 1.27 million deaths annually around the globe and has been recognized as a top 3 priority health threat. Antimicrobial photodynamic therapy (aPDT) is considered a promising alternative to conventional antibiotic treatments. Algal lipid extracts have shown antibacterial effects when used as photosensitizers (PSs) in aPDT. In this work we assessed the photodynamic efficiency...


Insight into the efficiency of microalgae’ lipidic extracts as photosensitizers...

Mendonça, Inês; Silva, Daniela; Conde, Tiago; Maurício, Tatiana; Cardoso, Helena; Pereira, Hugo; Bartolomeu, Maria; Vieira, Cátia; Domingues, M. Rosário

Antibacterial resistance causes around 1.27 million deaths annually around the globe and has been recognized as a top 3 priority health threat. Antimicrobial photodynamic therapy (aPDT) is considered a promising alternative to conventional antibiotic treatments. Algal lipid extracts have shown antibacterial effects when used as photosensitizers (PSs) in aPDT. In this work we assessed the photodynamic efficiency...


Wastewater disinfection with photodynamic treatment and evaluation of its ecoto...

Bartolomeu, Maria; Gomes, Thierry J.; Campos, Fábio; Vieira, Cátia; Loureiro, Susana; Neves, M. Graça P. M. S.; Faustino, M. Amparo F.

Research has demonstrated the presence of viruses in wastewater (WW), which can remain viable for a long period, posing potential health risks. Conventional WW treatment methods involving UV light, chlorine and ozone efficiently reduce microbial concentrations, however, they produce hazardous byproducts and microbial resistance that are detrimental to human health and the ecosystem. Hence, there is a need for n...


Effect of β-cyclodextrin on the CO release kinetics and antimicrobial activity ...

Monteiro, Rodrigo P.; Calhau, Isabel B.; Gomes, Ana C.; Pereira, Carla; Vieira, Cátia; Faustino, M. Amparo F.; Almeida, Adelaide; Pillinger, Martyn

In the present work the possibility of improving the solubility, bioavailability and bactericidal activity of the carbon monoxide releasing molecule (CORM) [Mo(CO)5Br]− (as its tetraethylammonium salt) (1) by solvent-free co-grinding with β-cyclodextrin (βCD) in a planetary ball mill was investigated. Data obtained by FT-IR spectroscopy, Raman spectroscopy, powder X-ray diffraction and thermogravimetric analysi...


Investigation of the potential of deep eutectic solvents (DES) as alternative s...

Vieira, Cátia; Bartolomeu, Maria; Pedro, Sónia N.; Gomes, Ana T. P. C.; Dias, Cristina J.; Gamelas, Sara R. D.; Lourenço, Leandro M. O.

Antimicrobial Photodynamic Therapy (aPDT) is gaining recognition as an effective approach for the photoinactivation of a broad spectrum of microorganisms [1,2]. Due to their apolar behavior, photosensitizers (PS) often have low solubility in aqueous media requiring the use of toxic organic solvents that are incompatible with their application in the field [4]. In this study, the potential of Deep Eutectic Solve...


Enhancing bacterial photodynamic inactivation through combined action of potass...

Gamelas, Sara R. D.; Bartolomeu, Maria; Vieira, Cátia; Faustino, Maria A. F.; Tomé, João P. C.; Tomé, Augusto C.; Almeida, Adelaide

Infectious diseases remain a leading cause of death all around the world. Over the last three decades, the alarming and escalating emergence of antibiotic-resistant bacterial strains has caused some concern among the scientific community [1,2]. Photodynamic inactivation (PDI) emerges as an alternative for inactivating microorganisms, including bacteria [1–3]. The use of phthalocyanine (Pc) derivatives as photos...


Deep Eutectic Solvents as alternative solvents in Antimicrobial Photodynamic Th...

Vieira, Cátia; Bartolomeu, Maria; Pedro, Sónia N.; Gomes, Ana T. P. C.; Dias, Cristina J.; Gamelas, Sara R. D.; Lourenço, Leandro M. O.


Photoinactivation of bacterial and fungal planktonic/biofilm forms using the co...

Vieira, Cátia; Bartolomeu, Maria; Santos, Adriele R.; Mesquita, Mariana Q.; Gomes, Ana T. P. C.; Neves, Maria Graça P. M. S.; Faustino, Maria Amparo F.

Antimicrobial photodynamic therapy (aPDT) is a promising approach against multidrug-resistant microorganisms. In this work, we accessed the photodynamic efficiency of an affordable formulation composed of five cationic porphyrins (FORM) and its combined effect with potassium iodide (KI) on a large spectrum of microorganisms. For this purpose, the aPDT assays were conducted with FORM alone and FORM + KI on plank...


Disinfection of wastewater in the mitigation of SARS-CoV-2 by photodynamic trea...

Almeida, Adelaide; Gomes, Marta; Bartolomeu, Maria; Vieira, Cátia; Gomes, Ana T. P. C.; Faustino, M. Amparo F.; Neves, M. Graça P. M. S.


Photodynamic inactivation of phage Phi6 as SARS-CoV-2 model in wastewater disin...

Bartolomeu, Maria; Vieira, Cátia; Gomes, Marta; Gomes, Ana T. P. C.; Faustino, Maria Amparo F.; Neves, Maria Graça P. M. S.; Almeida, Adelaide

The past 2 years have been marked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. This virus is found in the intestinal tract and reaches the wastewater system, and, consequently, the natural receiving water bodies, and inappropriate or/and inefficient WW treatment is a means of contamination. In the present work, we used a SARS-CoV-2 model—the phage Phi6—to evaluate its survival u...


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