6 documents found, page 1 of 1
APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmi...
O’Toole, Áine; Neher, Richard A.; Ndodo, Nnaemeka; Borges, Vitor; Gannon, Ben; Gomes, João Paulo; Groves, Natalie; King, David J.; Maloney, DanielHistorically, mpox has been characterized as an endemic zoonotic disease that transmits through contact with the reservoir rodent host in West and Central Africa. However, in May 2022, human cases of mpox were detected spreading internationally beyond countries with known endemic reservoirs. When the first cases from 2022 were sequenced, they shared 42 nucleotide differences from the closest mpox virus (MPXV) p...
Urgent need for a non-discriminatory and non-stigmatizing nomenclature for monk...
Happi, Christian; Adetifa, Ifedayo; Mbala, Placide; Njouom, Richard; Nakoune, Emmanuel; Happi, Anise; Ndodo, Nnaemeka; Ayansola, OyeronkeWe propose a novel, non-discriminatory classification of monkeypox virus diversity. Together with the World Health Organization, we named three clades (I, IIa and IIb) in order of detection. Within IIb, the cause of the current global outbreak, we identified multiple lineages (A.1, A.2, A.1.1 and B.1) to support real-time genomic surveillance.
Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/50...
O'Toole, Áine; Hill, Verity; Pybus, Oliver G.; Watts, Alexander; Bogoch, Issac I.; Khan, Kamran; Messina, Jane P.; Tegally, HouriiyahLate in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account f...
Importation and early local transmission of COVID-19 in Brazil, 2020
Jesus, Jaqueline Goes de; Sacchi, Claudio; Candido, Darlan da Silva; Claro, Ingra Morales; Sales, Flávia Cristina Silva; Manuli, Erika ReginaWe conducted the genome sequencing and analysis of the first confirmed COVID-19 infections in Brazil. Rapid sequencing coupled with phylogenetic analyses in the context of travel history corroborate multiple independent importations from Italy and local spread during the initial stage of COVID-19 transmission in Brazil.
Synonymous substitution rates predict HIV disease progression as a result of un...
Lemey, Philippe; Pond, Sergei L. Kosakovsky; Drummond, Alexei J.; Pybus, Oliver G.; Shapiro, Beth; Barroso, Helena; Taveira, Nuno; Rambaut, Andrew
Synonymous substitution rates predict HIV disease progression as a result of un...
Lemey, Philippe; Kosakovsky Pond, Sergei L.; Drummond, Alexei J.; Pybus, Oliver G.; Shapiro, Beth; Barroso, Helena; Taveira, Nuno; Rambaut, AndrewUpon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune res