13 documents found, page 1 of 2

From resistance to sensitivity in non-small cell lung cancer: newly established...

Background: Non-small cell lung cancer (NSCLC) is the most common form of lung cancer and presents a low 5-year survival rate [1]. Standard treatment of NSCLC includes chemotherapeutic drugs, such as taxanes and platinum-based agents. However, cancer cells may acquire resistance to multiple unrelated chemotherapeutic agents, known as multidrug resistance (MDR), which significantly limits treatment options [2]. ...

Development of a new application of the comet assay to assess levels of O6-meth...

O6-methylguanine (O6meG) is one of the most premutagenic, precarcinogenic, and precytotoxic DNA lesions formed by alkylating agents. Repair of this DNA damage is achieved by the protein MGMT, which transfers the alkyl groups from the O6 position of guanine to a cysteine residue in its active center. Because O6meG repair by MGMT is a stoichiometric reaction that irreversibly inactivates MGMT, which is subsequent...

Diet and DNA damage: in vivo effects of dietary compounds on isolated colonocyt...

Diet supplemented with UA or EGCG confer protection against DNA damage in colon...

Diet is an important factor in colorectal cancer. High fat diets are considered a risk factor for the development of colon cancer as they increase the content of bile acids in the colon. Bile acids have shown to induce the formation of reactive oxygen and nitrogen species, and these, in turn, induce DNA damage. On the other hand, diets rich in fruits and vegetables have shown preventive effects on colon cancer....

Diet and colon cancer - modulation of signaling pathways and DNA damage prevention

Colorectal cancer (CRC) is a common malignancy and significant cause of death in Western societies. It develops through an accumulation of genetic and epigenetic alterations, transforming normal cells and giving them growth advantage. Many food plants are rich in bioactive compounds and have shown to posses anticancer properties. We proposed to explore the effects of sage (Salvia officinalis (SO)) water extract...

DNA damage prevention and signaling pathway regulation by sage in a colon cance...

Colorectal cancer (CRC) is a common malignancy and significant cause of mortality in Western societies. It develops through an accumulation of genetic and epigenetic alterations, transforming normal colon cells and giving them growth advantage. Many food plants are rich in bioactive compounds and have shown to posses anticancer properties. We proposed to explore the effects of sage (Salvia officinalis (SO)) wat...

DNA damage protection and induction of repair by dietary phytochemicals and can...

Protective effects of ursolic acid and luteolin against oxidative DNA damage in...

Consumption of fruits and vegetables is associated with a reduced risk of developing a wide range of cancers including colon cancer. In this study, we evaluated the effects of two compounds present in fruits and vegetables, ursolic acid, a triterpenoid, and luteolin, a flavonoid, on DNA protection and DNA repair in Caco-2 cells using the comet assay. Ursolic acid and luteolin showed a protective effect against ...

Sage tea drinking improves lipid profile and antioxidant defences in Humans

Salvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40-50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes’ SOD and CAT activities and on Hsp70 expressio...

Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: eval...

In the present study, the chemoprotective effects of quercetin, rutin and ursolic acid on tert-butyl hydroperoxide (t-BHP)-induced DNA damage in a human hepatoma cell line (HepG2) were investigated by the comet assay. To determine whether protection was due to direct chemical interactions alone or to cellular-mediated responses three different types of treatments were used: simultaneous incubation of cells with...