13 documents found, page 1 of 2

Genomic epidemiology of Staphylococcus aureus from the Iberian Peninsula highli...

Staphylococcus aureus is a versatile pathobiont, exhibiting a broad host range, including humans, other mammals, and avian species. Host specificity determinants, virulence, and antimicrobial resistance genes are often shared by strains circulating at the animal-human interface. While transmission dynamics studies have shown strain exchange between humans and livestock, knowledge of the source, genetic diversif...

Metagenomic profiling of raw wastewater in Portugal highlights microbiota and r...

In response to the rapid emergence and dissemination of antimicrobial resistant bacteria (ARB) and genes (ARGs), integrated surveillance systems are needed to address antimicrobial resistance (AMR) within the One Health Era. Wastewater analyses enable biomarker monitoring at the sewershed level, offering timely insights into pathogen circulation and ARB/ARGs trends originating from different compartments. Durin...

The mobilome of Staphylococcus aureus from wild ungulates reveals epidemiologic...

Staphylococcus aureus thrives at animal-human-environment interfaces. A large-scale work from our group indicated that antimicrobial resistance (AMR) in commensal S. aureus strains from wild ungulates is associated with agricultural land cover and livestock farming, raising the hypothesis that AMR genes in wildlife strains may originate from different hosts, namely via exchange of mobile genetic elements (MGE)....

Antimicrobial resistance phylodynamics and source attribution under a One Healt...

Antimicrobial resistance (AMR) is a significant public health threat and has recently been recognized as a One Health issue, reflecting the interconnected nature of human, animal, and environmental health. This thesis aimed to increase knowledge on the burden, drivers and transmission dynamics of AMR at the human-animal-environment interfaces, for which Staphylococcus aureus, wild ungulates and genomics were ce...

Antimicrobial resistance in commensal Staphylococcus aureus from wild ungulates...

Staphylococcus aureus is a human pathobiont (i.e., a commensal microorganism that is potentially pathogenic under certain conditions), a nosocomial pathogen and a leading cause of morbidity and mortality in humans. S. aureus is also a commensal and pathogen of companion animals and livestock. The dissemination of antimicrobial resistant (AMR) S. aureus, particularly methicillin-resistant (MRSA), has been associ...

Enterotoxin- and Antibiotic-Resistance-Encoding Genes Are Present in Both Coagu...

Food poisoning by staphylococcal enterotoxins (SE) is a major cause of foodborne illness, often associated with coagulase-positive staphylococci (CPS). The increase in the number of methicillin-resistant Staphylococcus aureus (MRSA) strains is another major problem associated with CPS. However, reports of the association of SE and methicillin-resistant Staphylococcus with coagulase-negative staphylococci (CNS) ...

À superfície (2022): Aldeia Mineira do Lousal

The hard numbers of tuberculosis epidemiology in wildlife: A meta‐regression an...

Tuberculosis (TB) is a widespread disease that crosses the human and animal health boundaries, with infection being reported in wildlife, from temperate and subtropical to arctic regions. Often, TB in wild species is closely associated with disease occurrence in livestock but the TB burden in wildlife remains poorly quantified on a global level. Through meta-regression and systematic review, this study aimed to...

Revisiting the expression signature of pks15/1 unveils regulatory patterns cont...

One of the most important and exclusive characteristics of mycobacteria is their cell wall. Amongst its constituent components are two related families of glycosylated lipids, diphthioceranates and phthiocerol dimycocerosate (PDIM) and its variant phenolic glycolipids (PGL). PGL have been associated with cell wall impermeability, phagocytosis, defence against nitrosative and oxidative stress and, intriguingly, ...

Estimates of the global and continental burden of animal tuberculosis in key li...

Zoonotic animal tuberculosis (TB) is a One Health paradigm infectious disease, caused by Mycobacterium tuberculosis complex bacteria, that affects different host species with varying levels of management. In most developed countries, official surveillance and control strategies support the longitudinal reporting of herd and/or animal prevalence. However, for under resourced countries without surveillance plans,...