3 documents found, page 1 of 1
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iN...
Paiva, Ricardo S.; Ramos, Camila V.; Azenha, Sara R.; Alves, Carolina; Basto, Afonso; Graca, Luis; Martins, Vera C.Peptidyl-prolyl cis-trans isomerase C (Ppic) is expressed in several bone marrow (BM) hematopoietic progenitors and in T-cell precursors. Since the expression profile of Ppic in the hematoimmune system was suggestive that it could play a role in hematopoiesis and/or T lymphocyte differentiation, we sought to test that hypothesis in vivo. Specifically, we generated a Ppic-deficient mouse model by targeting the e...
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iN...
Paiva, Ricardo S.; Ramos, Camila V.; Azenha, Sara R.; Alves, Carolina; Basto, Afonso P.; Graça, Luís; Martins, Vera C.Peptidyl-prolyl cis-trans isomerase C (Ppic) is expressed in several bone marrow (BM) hematopoietic progenitors and in T-cell precursors. Since the expression profile of Ppic in the hematoimmune system was suggestive that it could play a role in hematopoiesis and/or T lymphocyte differentiation, we sought to test that hypothesis in vivo. Specifically, we generated a Ppic-deficient mouse model by targeting the e...
EpiLog: A software for the logical modelling of epithelial dynamics
Varela, Pedro L.; Ramos, Camila V.; Monteiro, Pedro T.; Chaouiya, ClaudineCellular responses are governed by regulatory networks subject to external signals from surrounding cells and to other micro-environmental cues. The logical (Boolean or multi-valued) framework proved well suited to study such processes at the cellular level, by specifying qualitative models of involved signalling pathways and gene regulatory networks. Here, we describe and illustrate the main features of EpiL...