Background: In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects durin...
BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57B...
The alveolar surfactant, which composition consists of a unique and complex mixture of lipids and proteins, has immunomodulatory action. This study aimed to evaluate the effects of exogenous surfactant on pulmonary inflammatory response in mice exposed to cigarette smoke (CS). Twenty-four mice C57BL/6 were divided into four groups: control group exposed to ambient air (CG); surfactant treated group (SG); CS exp...
Programa de Pós-Graduação em Saúde e Nutrição. Escola de Nutrição, Universidade Federal de Ouro Preto.; A fumaça de cigarro (FC) é considerada o maior fator de risco para o desenvolvimento de doença pulmonar obstrutiva crônica (DPOC). A FC apresenta uma mistura complexa de mais de 7000 compostos químicos. Entre esses, encontram-se um grande número de espécies reativas de oxigênio (EROs) que leva ao desencadeame...
Twenty-eight Fischer male rats were divided into four groups: control group (CG), exposed to the ambient air, and groups exposed to formaldehyde (FA) at concentrations of 1% (FA1%), 5% (FA5%) and 10% (FA10%). Kidney function was assessed by dosage of uric acid, creatinine and urea. Morphometry was performed on the thickness of the lumen of Bowman's capsule and diameter of the lumen of the renal tubules. We eval...
Avaliar a associação entre medidas antropométricas, de composição corporal, bioquímicas e de consumo alimentar em indivíduos com excesso de peso. Métodos: Estudo do tipo transversal, com amostra de conveniência composta por 31 indivíduos, com idade entre 19 e 59 anos. Foram realizadas avaliações antropométricas, bioquímicas e análise da composição da dieta. Após, foi calculado o índice de qualidade da dieta (IQ...