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Evolution of the human immunodeficiency virus type 2 envelope in the first year...

"Background: Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and ...

Evolution of the human immunodeficiency virus type 2 envelope in the first year...

Background Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and re...

Importance of C-C chemokine receptor 8 (CCR8) as an alternative coreceptor for ...

Envelope-specific antibody response in HIV-2 infection

Objective: To examine the unspecific and envelope-specific IgA and IgG responses in acute and chronic HIV-2 infection. Methods: Twenty-eight chronically infected adults and two children with perinatal infection were studied. Total plasma concentrations of. - Fundacao para a Ciencia e Tecnologia [POCTI/ESP/48045]. - The present work was supported by Fundacao para a Ciencia e Tecnologia (project POCTI/ESP/48045)....

Kikuchi-Fujimoto disease.

Kikuchi and Fujimoto's disease, also known as histiocytic necrotizing lymphadenopathy, is a rare and benign disorder of the lymph nodes of young adults. The etiology of this disease is unknown, an autoimmune mechanism has been suggested, although some cases of association with several viruses has been described. We report a pediatric case of Kikuchi and Fujimoto's disease in a 14 years old girl with persistent ...

HIV infection in pregnant women and children

The use of antiretroviral therapy during pregnancy, cesarean delivery and not breastfeeding made ??possible, in most developed countries, reduce the rate of perinatal transmission.; A utilização de terapêutica anti-retrovírica durante a gravidez, a cesareana e a não amamentação tornaram possível, nos países mais desenvolvidos, reduzir a taxa de transmissão peri-natal.

Evaluation of the clinical sensitivities of three viral load assays with plasma...

The viral load assays AMPLICOR HIV-1 Monitor Test 1.5, Nuclisens HIV-1 QT, and Quantiplex HIV RNA 3.0 (bDNA) were evaluated for their abilities to quantify human immunodeficiency virus type 1 (HIV-1) RNA in 64 plasma samples from 21 children infected in Portugal. The children were infected with HIV-1 subtypes A1, B, F1, G, and BG recombinant virus. AMPLICOR v1.5 and Quantiplex v3.0 detected all samples, and the...