46 documents found, page 1 of 5

Transmural Remission Improves Clinical Outcomes Up to 5 years in Crohn's Disease

Introduction: Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. Methods: Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colon...

Tofacitinib: an Option for Acute Severe Ulcerative Colitis?

Tofacitinib has emerged as a new option for ulcerative colitis. Its rapid absorption, metabolism, and clinical improvement make it an interesting option for rescue therapy in acute severe ulcerative colitis (ASUC), a situation with limited therapeutic options in patients with a long-term disease course and multiple drug failure. The management of ASUC in this setting becomes challenging, underlying the need for...

Low Golimumab Trough Levels at Week 6 Are Associated With Poor Clinical, Endosc...

Background and aims: Golimumab has an established exposure-response relationship in patients with ulcerative colitis [UC]. However, the association of serum golimumab trough levels [TL] with objective markers of disease activity, such as endoscopic and histological activity scores and concentrations of biomarkers, remains less understood. This report describes the relationship of serum golimumab TL at the end o...

A Narrative Review on Anti-Tumor Necrosis Factor α Therapies in Inflammatory Bo...

INTRODUCTION: Inflammatory bowel disease activity is associated with adverse pregnancy outcomes. Anti-tumor necrosis factor α therapy is often required to treat flares and to maintain disease remission. However, there are concerns regarding treatment with these agents during pregnancy, as they actively cross the placental barrier. MATERIAL AND METHODS: Studies regarding anti-tumor necrosis factor α therapy duri...

Soluble Human Suppression of Tumorigenicity 2 Is Associated with Endoscopic Act...

Background: Suppressor of Tumorigenicity 2 (ST2) is an IL33 receptor detected in the mucosa and serum of ulcerative colitis (UC) patients. We evaluated soluble ST2 (sST2) as a surrogate biomarker of disease outcome and therapeutic response, in moderate-to-severe UC patients treated with golimumab. Methods: We conducted an open-label single-arm multicentre prospective study. At screening/baseline, week 6 (W6) an...

Primary HIV Infection in a Crohn's Disease Patient Receiving Infliximab Mainten...

Safe Use of Infliximab for the Treatment of Severe Perianal Crohn's Disease Aft...

Inflammatory bowel disease is associated with an increased likelihood of developing lymphoma. However, it is still controversial if this risk may be attributed to the disease itself or rather represents an effect of immunosuppressive treatment. Although tumor necrosis factor alpha (TNFα) is a key cytokine for cancer immunosurveillance, the potential relationship between anti-TNFα agents and the pathogenesis of ...

Lymphoproliferative Disorders in Inflammatory Bowel Disease Patients: Is It the...

Introduction: Systemic inflammatory diseases are related to an increased risk of lymphoproliferative disorders. Although inflammatory bowel disease (IBD) was also associated with these conditions, population-based studies failed to demonstrate this relationship, and most studies only identified a very small number of cases. In the last few years, concerns arose regarding the role of thiopurines and tumour necro...

Qualidade da Informação Contida nas Referenciações dos Cuidados de Saúde Primár...

Introdução: Em Portugal, os médicos de fa- mília são a principal fonte de referenciação de casos para os serviços de saúde mental. A qua- lidade da referenciação pode ter consequên- cias, tanto para o médico de medicina geral e familiar que referencia o utente, como para o psiquiatra que o irá receber, e sobretudo para o utente referenciado. Objetivos: Avaliar a qualidade da informação contida nas cartas de ref...

The who-when-why triangle of CAM use among Portuguese IBD patients

The use of complementary and alternative medicines is increasing among chronic patients, particularly those afflicted with inflammatory bowel diseases. AIM: This study aimed to address the prevalence of complementary and alternative medicines use among Portuguese inflammatory bowel diseases' patients. METHODS: Patients were invited to fill an anonymous questionnaire concerning the use of complementary and alter...