Encontrados 2 documentos, a visualizar página 1 de 1
Soft culture substrates favor stem-like cellular phenotype and facilitate repro...
Gerardo, Heloísa; Lima, Ana; Carvalho, João; Ramos, João R. D.; Couceiro, Sofia; Travasso, Rui D.; Neves, Ricardo Pires das; Grãos, MárioBiophysical cues influence many aspects of cell behavior. Stiffness of the extracellular matrix is probed by cells and transduced into biochemical signals through mechanotransduction protein networks, strongly influencing stem cell behavior. Cellular stemness is intimately related with mechanical properties of the cell, like intracellular contractility and stiffness, which in turn are influenced by the microenv...
Capillary network formation from dispersed endothelial cells: Influence of cell...
Ramos, João R. D.; Travasso, Rui; Carvalho, JoãoThe formation of a functional vascular network depends on biological, chemical, and physical processes being extremely well coordinated. Among them, the mechanical properties of the extracellular matrix and cell adhesion are fundamental to achieve a functional network of endothelial cells, able to fully cover a required domain. By the use of a Cellular Potts Model and Finite Element Method it is shown that ther...