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The role of natural compounds in rat mammary cancer: the beneficial effects of ...

Azevedo, Tiago; Silva, J; Faustino-Rocha, Ana I; Valada, A; Anjos, L; Moura, T; Ferreira, T; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F

Breast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, includ- ing anticancer and anti-diabetic properties. This study aimed to assess the chemopreven- tive effects of S. chamaecyparissus aqueous ex- tract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were...


Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemica...

Azevedo, T; Faustino-Rocha, Ana I; Silva, J; Valada, A; Anjos, L; Moura, T; Ferreira, R; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F; Seixas, F

Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemically- induced mammary cancer


Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemica...

Azevedo, T; Faustino-Rocha, Ana I; Silva, J; Valada, A; Anjos, L; Moura, T; Ferreira, R; Santos, M; Pires, MJ; Neuparth, MJ; Peixoto, F; Seixas, F

Chemopreventive effects of Santolina chamaecyparissus in a rat model of chemically- induced mammary cancer.


OPTImized Coronary Interventions EXplaIn the BEst CliNical OutcomEs (OPTI-XIENC...

Moreno, R; Bravo Baptista, S; Valencia, J; Gomez-Menchero, A; Bouisset, F; Ruiz-Arroyo, JR; Bento, A; Besutti, M; Jimenez-Valero, S; Rivero-Santana, B

Introduction: Clinical events may occur after percutaneous coronary intervention (PCI), particularly in complex lesions and complex patients. The optimization of PCI result, using pressure guidewire and intracoronary imaging techniques, may reduce the risk of these events. The hypothesis of the present study is that the clinical outcome of patients with indication of PCI and coronary stent implantation that are...


How to Delineate the General Profiles of Functionality of Citizen’s Aged 65 Yea...

Goes, M.; Lopes, M.; Oliveira, H.; Marôco, J.; Fonseca, C.; Santos, M; Caeiro, C.

Objectives: A core set of International Classification of Functioning, Disability and Health codes was used, to ascertain the general profile of functionality as a function of biological and sociodemographic characteristics, notably the age of the citizens. Methods: Data were collected by health professionals in the participants’ houses. The factorial validity of the construct was assessed by a confirmatory fac...


Radiopharmaceutical extravasation in bone scintigraphy: a cross-sectional study

Fernandes, D; Santos, M; Pinheiro, M; Duarte, H; Fontes, F

Objetives Tc-99m Hydroxymethylene diphosphonate (HMDP) bone scintigraphy is commonly used to diagnose bone disorders. We aimed to quantify and characterize the occurrence of radiopharmaceutical extravasation in bone scintigraphy, using Tc-99m HMDP, as well as to compare the visual classification of the events with an independent analysis using image processing software.Methods We conducted a cross-sectional stu...


Neuroimaging Findings in Paediatric Patients with Sickle Cell Disease

Abreu, VS; Xavier, S; Santos, M; Lopes da Silva, R; Kjöllerström, P; Conceição, C

Sickle cell disease (SCD) is an autosomal recessive haemoglobinopathy, which manifests as multisystem ischaemia and infarction, as well as haemolytic anaemia. The morphological changes of red blood cells (RBCs) that promote ischaemia/infarction as the main multi-systemic manifestation, with associated vasculopathy, may also lead to haemorrhage and fat embolisation. Bone infarctions, whether of the skull or spin...


Acute Coronary Syndrome and Stress: Is There a Relationship?

Santos, H; Santos, M; Paula, S; Figueiredo, M; Almeida, I; Miranda, H; Chin, J; Sá, C; Neto, M; Almeida, S; Sousa, C; Almeida, L

Introduction: Acute coronary syndrome (ACS) is the result of a complex pathophysiological process with various dynamic factors. The 10-item Perceived Stress Scale (PSS-10) is a validated instrument for estimating stress levels in clinical practice and may be useful in the assessment of ACS. Methods: We carried out a single-center prospective study engaging patients hospitalized with ACS between March 20, 2019 a...


Air Pollution and Cardiovascular Diseases: a Position Paper

Caldeira, D; Franco, F; Bravo Baptista, S; Cabral, S; Cachulo, MC; Dores, H; Peixeiro, A; Rodrigues, R; Santos, M; Timóteo, AT; Vasconcelos, J

Air pollution is one of the main environmental risk factors for health and is linked to cardiovascular diseases, which are the leading cause of mortality worldwide. In this position paper, we discuss the main air pollutants and how they can promote the development of cardiovascular disease or cardiovascular events. We also summarise the main evidence supporting the association between air pollution and cardiova...


Late Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide ...

Santos, E; Moura, J; Samões, R; Sousa, AP; Mendonça, T; Abreu, P; Guimarães, J; Correia, I; Durães, J; Sousa, L; Ferreira, J; de Sá, J; Sousa, F

Introduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMO...


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