4 documents found, page 1 of 1
Rastreio Auditivo Neonatal em 17 732 Recém-Nascidos
Gabriel, T; Martins, E; Carvalho, G; Fontes, N; Ramos, MJ; Peres, M; Moura, I; Rêgo, J; Guimarães, A; Freire, FIntrodução: A surdez infantil representa uma das anomalias congénitas mais frequentes. Em Portugal, foi desenvolvido o Grupo de Rastreio e Intervenção na Surdez Infantil (GRISI), cujo principal objetivo é implementar um programa de rastreio nacional através da aplicação de técnicas e métodos definidos e semelhantes nos vários hospitais. Objetivos: Analizar a polupação de recém-nascidos rastreados num hospital p...
vsLab-An Implementation for Virtual High-Throughput Screening Using AutoDock an...
Nuno M F S A Cerqueira; Ribeiro, J; Pedro A Fernandes; Ramos, MJMolecular docking is a key tool in structural molecular biology and computer-assisted drug design. The goal of ligand-protein docking is to predict the predominant binding mode(s) of a ligand with a protein of known three-dimensional structure. There is much docking software that has been successfully used in a myriad of keystone problems; however, as commonly happens with most of the scientific software, the p...
Substrate Recognition in HIV-1 Protease: A Computational Study
Perez, MAS; Fernandes, PA; Ramos, MJHIV-1 protease is a crucial enzyme for the life cycle of the human immunodeficiency virus, the retrovirus that triggers AIDS. It is well documented that HIV-1 protease mediates the cleavage of Gag, Gag-Pol, and Nef precursor polyproteins and is highly selective concerning the set of 12 different amino acid sequences that cleaves. However, the governing principles and physical parameters, which determine substra...
Understanding the Mechanism for Ribonucleotide Reductase Inactivation by 2 '-De...
Perez, MAS; Pedro A Fernandes; Ramos, MJRibonucleotide reductase (RNR) is the key enzyme in the biosynthesis of deoxyribonucleotides. The enzyme has thus an attractive target for chemotherapies that fight proliferation-based diseases. 2'-Deoxy-2'-methylenecytidine-5'-diphosphate (CH(2)dCDP) is a potent mechanism-based inhibitor of the enzyme RNR, which decomposes to an active alkylating furanone specie. The details of the inhibition mechanism are unk...