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Side-effects of irinotecan (CPT-11), the clinically used drug for colon cancer ...

Alencar, Nylane Maria Nunes de; Bitencourt, Flávio da Silveira; Figueiredo, Ingrid Samantha Tavares de; Luz, Patrícia Bastos

Intestinal mucositis (IM) is the critical side effect of irinotecan (CPT-11), which is the front-line drug used for the treatment of colorectal cancer. This study aimed to evaluate the effectiveness of latex proteins (LP) from Calotropis procera to prevent IM and diarrhea in animals. Swiss mice were treated daily with saline or LP (1, 5, or 50 mg/kg, i.v.) 24 h prior to CTP-11 (75 mg/kg/4 days, i.p) and for add...

Date: 2017   |   Origin: Oasisbr
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