4 documents found, page 1 of 1
Decreased dihydroartemisinin-piperaquine protection against recurrent malaria a...
Pernaute-Lau, Leyre; Recker, Mario; Tékété, Mamadou; de Sousa, Taís Nóbrega; Traoré, Aliou; Fofana, Bakary; Sanogo, Kassim; Morris, UlrikaDihydroartemisinin-piperaquine (DHA-PPQ) is being recommended in Africa for the management of uncomplicated Plasmodium falciparum malaria and for chemoprevention strategies, based on the ability of piperaquine to delay re-infections. Although therapeutic resistance to piperaquine has been linked to increased copy number in plasmepsin-coding parasite genes (pfpm), their effect on the duration of the post-treatme...
Inglês Inglês
da Fonseca, Beatriz Velosa; Mendes Veiga, Maria Isabel; Baptista, Vitória; Pernaute-Lau, Leyre; Osório, Nuno; Calçada, CarlaMalaria, a devastating illness remains a global health concern with an estimated 249 million malaria cases in 85 malaria-endemic countries around the world. Malaria elimination, challenged by drug resistance, requires strategic interventions that could be the implementation of antimalarials with selective actions on the different phases of the parasite life cycle. Of particular relevance is gametocytocidal drug...
Inglês Inglês
da Fonseca, Beatriz Velosa; Mendes Veiga, Maria Isabel; Baptista, Vitória; Pernaute-Lau, Leyre; Osório, Nuno; Calçada, CarlaMalaria, a devastating illness remains a global health concern with an estimated 249 million malaria cases in 85 malaria-endemic countries around the world. Malaria elimination, challenged by drug resistance, requires strategic interventions that could be the implementation of antimalarials with selective actions on the different phases of the parasite life cycle. Of particular relevance is gametocytocidal drug...
Resistance to antimalarials : a pharmacogenomics approach for both parasite and...
Pernaute-Lau, LeyreMalaria is a vector-borne disease that affected up to 241 million people just last year, causing more than 602 thousand deaths in Africa alone. Global strategies for malaria control include artemisinin-based combination therapies (ACTs) as the recommended first line treatment for uncomplicated Plasmodium falciparum malaria. Unfortunately, drug resistance remains a recurring obstacle. An area still under-studied...