7 documents found, page 1 of 1
The modulatory role of internet-supported mindfulness-based cognitive therapy o...
Pereira, Diana R.; Silva, Eunice R.; Carvalho-Maia, Carina; Monteiro-Reis, Sara; Lourenço, Catarina; Calisto, Rita; Teixeira, Ricardo JoãoMindfulness-based interventions (MBIs) have been used in oncology contexts as a promising tool with numerous benefits for various health-related and psychosocial outcomes. Despite the increasing popularity of MBIs, few randomized controlled trials (RCTs) have examined their effects upon biological parameters. Specifically, no previous study has examined the effects of MBIs on extracellular vesicles (EVs), which...
An ArchiMate-Based Approach to ISO 9001:2015 Quality Management: Shifting to IT...
Pereira, Ana; Henriques, Rui T.; Barata, JoaoThis paper presents an approach to document ISO 9001:2015 quality management systems (QMS) using ArchiMate. The research is done in cooperation with a research and technology development institute developing ISO 9001:2015-compliant information systems. The models and the steps needed to adopt an enterprise architecture approach to ISO 9001:2015 are demonstrated for the aeronautical setting. ISO 9001:2015 sugges...
Secreted Extracellular Vesicle Molecular Cargo as a Novel Liquid Biopsy Diagnos...
Monteiro-Reis, Sara; Carvalho-Maia, Carina; Bart, Genevieve; Vainio, Seppo J.; Pedro, Juliana; Silva, Eunice R.; Sales, Goreti; Henriques, Rui T.Secreted extracellular vesicles (EVs) are heterogeneous cell-derived membranous granules which carry a large diversity of molecules and participate in intercellular communication by transferring these molecules to target cells by endocytosis. In the last decade, EVs' role in several pathological conditions, from etiology to disease progression or therapy evasion, has been consolidated, including in central nerv...
Liquid Biopsies in the Clinical Management of Germ Cell Tumor Patients: State-o...
Lobo, João; Leão, Ricardo; Jerónimo, Carmen; Henriques, Rui T.Liquid biopsies constitute a minimally invasive means of managing cancer patients, entailing early diagnosis, follow-up and prediction of response to therapy. Their use in the germ cell tumor field is invaluable since diagnostic tissue biopsies (which are invasive) are often not performed, and therefore only a presumptive diagnosis can be made, confirmed upon examination of the surgical specimen. Herein, we pro...
Extracellular Vesicle Proteome in Prostate Cancer: A Comparative Analysis of Ma...
Bernardino, Rui Miguel Marques; Leão, Ricardo; Henriques, Rui T.; Pinheiro, Luis Campos; Kumar, Prashant; Suravajhala, Prashanth; Beck, Hans ChristianMolecular diagnostics based on discovery research holds the promise of improving screening methods for prostate cancer (PCa). Furthermore, the congregated information prompts the question whether the urinary extracellular vesicles (uEV) proteome has been thoroughly explored, especially at the proteome level. In fact, most extracellular vesicles (EV) based biomarker studies have mainly targeted plasma or serum. ...
The solid solutions (Per)(2)[PtxAu(1-x)(mnt)(2)]; alloying para-and diamagnetic...
Matos, Manuel; Bonfait, Gregoire; Santos, Isabel C.; Afonso, Monica L.; Henriques, Rui T.; Almeida, ManuelThe alpha-(Per)(2)[M(mnt)(2)] compounds with M = Pt and Au are isostructural two-chain solids that in addition to partially oxidized conducting perylene chains also contain anionic chains that can be either paramagnetic in the case of M = Pt or diamagnetic for M = Au. The electrical transport and magnetic properties of the solid solutions (Per)(2)[Pt-x-Au(1-x)(mnt)(2)] were investigated. The incorporation of pa...
N,N'-Ethylenebis(pyridoxylideneiminato) and N,N'-Ethylenebis(pyridoxylaminato):...
Correia, Isabel; Pessoa, João Costa; Duarte, M. Teresa; Henriques, Rui T.; Piedade, M. Fátima M.; Veiros, Luís F.; Jakusch, Tamás; Kiss, TamásThe Schiff base N,Nprime-ethylenebis(pyridoxylideneiminato) (H2pyr2en, 1) was synthesized by reaction of pyridoxal with ethylenediamine; reduction of H2pyr2en with NaBH4 yielded the reduced Schiff base N,Nprime-ethylenebis(pyridoxylaminato) (H2Rpyr2en, 2); their crystal structures were determined by X-ray diffraction. The totally protonated forms of 1 and 2 correspond to H6L4+, and all protonation constants wer...