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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Diso...
Mullins, Niamh; Kang, JooEun; Campos, Adrian I; Coleman, Jonathan R I; Edwards, Alexis C; Galfalvy, Hanga; Levey, Daniel F; Lori, AdrianaBackground: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) c...
Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomy...
Sakurai, Takeshi; Ramoz, Nicolas; Barreto, Marta; Gazdoiu, Mihaela; Takahashi, Nagahide; Gertner, Michael; Dorr, Nathan; Gama Sosa, Miguel A.BACKGROUND: SLC25A12, a susceptibility gene for autism spectrum disorders that is mutated in a neurodevelopmental syndrome, encodes a mitochondrial aspartate-glutamate carrier (aspartate-glutamate carrier isoform 1 [AGC1]). AGC1 is an important component of the malate/aspartate shuttle, a crucial system supporting oxidative phosphorylation and adenosine triphosphate production. METHODS: We characterized mice wi...