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Genetics- and age-driven neuroimmune and disc changes underscore herniation sus...
Novais, Emanuel J.; Ottone, Olivia K.; Brown, Eric V.; Madhu, Vedavathi; Tran, Victoria A.; Ramteke, Pranay; Dighe, Abhijit S.; Solga, Michael D.There are no appropriate mouse models to study the pathophysiology of spontaneous disc herniations in a wild-type setting. SM/J mice, a poor healer inbred strain, presented a high incidence of age-associated lumbar disc herniations with neurovascular innervations. Transcriptomic comparisons of the SM/J annulus fibrosus with human tissues showed shared pathways related to immune cell activation and inflammation....
Date: 2025
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Origin: Veritati - Repositório Institucional da Universidade Católica Portuguesa