Malaria continues to be the principal cause of morbidity and mortality in Angola, primarily due to Plasmodium falciparum (Pf) infection. Angola ranked 9th worldwide in number of malaria deaths in 2021 but the distribution of disease is remarkably heterogeneous, with provinces varying between <1% and >50% malaria prevalence. Despite malaria’s heavy toll on public health in Angola, Pf genetic diversity and demogr...