10 documents found, page 1 of 1
Ferulic acid lowers body weight and visceral fat accumulation via modulation of...
Melo, T. S. de; Lima, P. R.; Carvalho, K. M. M. B.; Fontenele, T. M.; Solon, F. R. N.; Tomé, A.R.; Lemos, T. L. G. de; Fonseca, S. G. da CruzPrevious studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been fi rmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20 – 25 g (n=6 – 8 per group) were fed a normal diet (ND) or H...
The triterpenoid alpha, beta-amyrin prevents the impaired aortic vascular react...
Santos, Flávia Almeida; Batista-Lima, Francisco José; Nunes, Paulo Iury Gomes; Viana, Ana Flávia Seraine CustódioTo characterize the pro tective effects of the triterpenoid mixture alpha, beta-amyrin (AMY, 20 mg/kg, during 15 days) on the reactivity of isolated aorta of high- fat diet (HFD)-induced obese mice. Male Swiss mice were fed with HFD or normal diet (ND) for 15 weeks. Contractions of thoracic aorta in response to KCl or phen- ylephrine (PHE) and relaxation by acetylcholine (ACh) or sodium nitroprusside (SNP) were...
The resin from protium heptaphyllum prevents high-fat diet-induced obesity in m...
Carvalho, Karine Maria Martins Bezerra; MarinhoFilho, José Delano Barreto; Melo, Tiago Sousa de; Araújo, Ana Jérsia; Quetz, Josiane da SilvaHerbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolicdisorders.ThepresentstudyinvestigatedtheantiobesitypropertiesofresinfromProtiumheptaphyllum(RPH)andthe possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, netenergyintake,abdominalfataccumulation,plasmagluco...
Oleanolic Acid, a Pentacyclic Triterpene Attenuates the Mustard Oil-Induced Col...
David, Juceni Pereira de Lima; David, Jorge Mauricio; Lima Júnior, Roberto César Pereira; Santos, Flávia Almeida; Maia, Juliana LemosTexto completo: acesso restrito.p.82-85; Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-09-05T15:01:39Z No. of bitstreams: 1 _pdf.pdf: 202301 bytes, checksum: 96cc86d2f165688f542988affee41d78 (MD5); Approved for entry into archive by Alda Lima da Silva(sivalda@ufba.br) on 2013-09-16T19:52:54Z (GMT) No. of bitstreams: 1 _pdf.pdf: 202301 bytes, checksum: 96cc86d2f165688f542988affee41d78 (MD5); Made ...
Topical anti-inflammatory potential of Physalin E from Physalis angulata on exp...
Pinto, Natália Bitú; Morais, Talita Cavalcante; Carvalho, Karine Maria Martins Bezerra; Silva, Cecília Rocha; Andrade, Geanne Matos deThe anti-inflammatory effect of physalin E, a seco-steroid isolated from Physalis angulata L. was evaluated on acute and chronic models of dermatitis induced by 12-O-tetradecanoyl-phorbol-13- acetate (TPA) and oxazolone, respectively, in mouse ear. The changes in ear edema/thickness, production of pro-inflammatory cytokines (TNF- a and IFN- g ), myeloperoxidase (MPO) activity, and histological and immunohistoch...
Attenuation of capsaicin-induced acute and visceral nociceptive pain by a - and...
Oliveira, Francisco A.; Costa, Charllynton L.S.; Chaves, Mariana H.0; Almeida, Fernanda Regina de Castro; Cavalcante, Ítalo José MesquitaThe triterpene mixture, a - and h -amyrin, isolated from Protium heptaphyllum resin was evaluated on capsaicin- evoked nociception in mice. Orally administered a - and h -amyrin (3 to 100 mg/kg) significantly suppressed the nociceptive behaviors—evoked by either subplantar (1.6 A g) or intracolonic (149 A g) application of capsaicin. The antinociception produced by a - and h -amyrin against subplantar capsaicin...
Peripheral antinociceptive action of mangiferin in mouse models of experimental...
Lopes, Synara C.; Silva, Ana Virgínia Lima da; Arruda, Bruno Rodrigues; Morais, Talita Cavalcante; Rios, Jeison Barros Rioshis study aimed to assess the possible systemic antinociceptive activity of mangiferin and to clarify the un- derlying mechanism, using the acute models of chemical (acetic acid, formalin, and capsaicin) and thermal (hot-plate and tail- fl ick) nociception in mice. Mangiferin at oral doses of 10 to 100 mg/kg evidenced signif- icant antinociception against chemogenic pain in the test models of acetic acid-induce...
Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice in...
Morais, Talita Cavalcante; Lopes, Synara Cavalcante; Carvalho, Karine Maria Martins Bezerra; Arruda, Bruno Rodrigues; Souza, Francisco Thiago Correia deAIM: To investigate the effects of mangiferin on gas - trointestinal transit (GIT) in normal and constipated mice, together with the possible mechanism. METHODS: Intragastrically-administered charcoal mea was used to measure GIT in overnight starved Swiss mice. In the first experiments, mangiferin (3 mg/kg, 10 mg/kg, 30 mg/kg, and 100 mg/kg, po ) or tegaserod (1 mg/kg, ip ) were administered 30 min before the c...
Mangiferin ameliorates 6-hydroxydopamine- induced cytotoxicity and oxidative st...
Rao, Vietla Satyanarayana; Carvalho, Ana C. S.; Trevisan, Maria Teresa S.; Andrade, Geanne Matos de; Nobre Júnior, Hélio VitorianoMangiferin ameliorates 6-hydroxydopamine- induced cytotoxicity and oxidative stress in ketamine model of schizophrenia Vietla S. Rao 1 , Ana C. Carvalho 1 , Maria Teresa S. Trevisan 2 , Geanne M. Andrade 1 , Helio V. Nobre Júnior 1 , Manoel O. Moraes 1 , Hemerson I. Magalhães H. Iury 1 , Talita C. Morais 1 , Flavia A. Santos 1 1 Department of Physiology and Pharmacology, Federal University of Ceará, Cel Nunes d...
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nocicepti...
Maia, Juliana Lemos; Lima Júnior, Roberto César Pereira; Melo, Caroline Mourão; David, Juceni Pereira de Lima; David, Jorge MauricioRESTRITO; Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-07-10T14:48:21Z No. of bitstreams: 1 DD.pdf: 191921 bytes, checksum: e7e0d97358e281aeda5710f62c757522 (MD5); Made available in DSpace on 2012-07-10T14:48:21Z (GMT). No. of bitstreams: 1 DD.pdf: 191921 bytes, checksum: e7e0d97358e281aeda5710f62c757522 (MD5) Previous issue date: 2006; The anti-inflammatory pentacyclic triterpene, oleanoli...