3 documents found, page 1 of 1
Aerocyte specification and lung adaptation to breathing is dependent on alterna...
Fidalgo, Marta F; Fonseca, Catarina; Caldas, Paulo; Raposo, Alexandre; Balboni, Tania; Henao Mišíková, Lenka; Grosso, Ana R.; Vasconcelos, FranciscaAdaptation to breathing is a critical step in lung function and it is crucial for organismal survival. Alveoli are the lung gas exchange units and their development, from late embryonic to early postnatal stages, requires feedbacks between multiple cell types. However, how the crosstalk between the alveolar cell types is modulated to anticipate lung adaptation to breathing is still unclear. Here, we uncovered a...
Tlx3 exerts direct control in specifying excitatory over inhibitory neurons in ...
Monteiro, Filipe A.; Miranda, Rafael M.; Samina, Marta C.; Dias, Ana F.; Raposo, Alexandre; Oliveira, Patrícia; Reguenga, Carlos; Castro, Diogo S.The spinal cord dorsal horn is a major station for integration and relay of somatosensory information and comprises both excitatory and inhibitory neuronal populations. The homeobox gene Tlx3 acts as a selector gene to control the development of late-born excitatory (dILB) neurons by specifying glutamatergic transmitter fate in dorsal spinal cord. However, since Tlx3 direct transcriptional targets remain largel...
Monozygotic twins concordant for common variable immunodeficiency : strikingly ...
Silva, Susana L.; Fonseca, Mariana; Pereira, Marcelo L. M.; Silva, Sara P.; Barbosa, Rita R.; Serra-Caetano, Ana; Blanco, Elena; Rosmaninho, PedroMonozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primary antibody defects displaying wide phenotypic and genetic heterogeneity, with monogenic transmission accounting for only a minority of the cases. Here, we report a ...