7 documents found, page 1 of 1
Loss of postprandial insulin clearance control by Insulin-degrading enzyme driv...
Borges, Diego O; Patarrão, Rita S; Ribeiro, Rogério T.; de Oliveira, Rita Machado; Duarte, Nádia; Belew, Getachew Debas; Martins, MadalenaSystemic insulin availability is determined by a balance between beta-cell secretion capacity and insulin clearance (IC). Insulin-degrading enzyme (IDE) is involved in the intracellular mechanisms underlying IC. The liver is a major player in IC control yet the role of hepatic IDE in glucose and lipid homeostasis remains unexplored. We hypothesized that IDE governs postprandial IC and hepatic IDE dysfunction am...
Lifestyle, metabolic disorders and male hypogonadism - a one-way ticket?
Crisóstomo, Luís; Pereira, Sara C.; Monteiro, Mariana P.; Raposo, João F.; Oliveira, Pedro F.; Alves, Marco G.Hypogonadism is more frequent among men with common metabolic diseases, notably obesity and type 2 diabetes. Indeed, endocrine disruption caused by metabolic diseases can trigger the onset of hypogonadism, although the underlying molecular mechanisms are not entirely understood. Metabolic diseases are closely related to unhealthy lifestyle choices, such as dietary habits and sedentarism. Therefore, hypogonadism...
Impact of combined training with different exercise intensities on inflammatory...
Magalhães, João P.; Santos, Diana A.; Correia, Inês; Hetherington-Rauth, Megan; Ribeiro, Rogério; Raposo, João F.; Matos, Andreia; Bicho, ManuelBackground: Exercise is a well-accepted strategy to improve lipid and infammatory profle in individuals with type 2 diabetes (T2DM). However, the exercise intensity having the most benefts on lipids and infammatory markers in patients with T2DM remains unclear. We aimed to analyse the impact of a 1-year combined high-intensity interval training (HIIT) with resistance training (RT), and a moderate continuous tra...
Biomarcadores cardiovasculares e da ingestão alimentar associados com a hiperte...
Valente, Ana; Bicho, Manuel; Duarte, Rui; Raposo, João F.; Costa, Helena S.A diabetes é um fator de risco da hipertensão arterial; (Cheung & Li, Curr Atheroscler Rep, 2012) Conhecer e relacionar os níveis plasmáticos de diversos biomarcadores (ex. cardiovasculares e da ingestão alimentar) pode contribuir para prevenir e controlar a hipertensão arterial em diabéticos tipo 2.
Biomarkers status and their relation with the presence of type 2 diabetes with ...
Valente, Ana; Bicho, Manuel; Duarte, Rui; Raposo, João F.; Costa, Helena S.The knowledge on the status of several biomarkers [1] is a useful tool for disease clinical characterization and treatment of type 2 diabetes. The additive clinical effect of the presence of different biomarkers can be used to evaluate the risk to develop angiopathy and also in disease management.
Frequência de polimorfismos genéticos de enzimas envolvidas no metabolismo da h...
Valente, Ana; Bicho, Manuel; Duarte, Rui; Raposo, João F.; Costa, H.S.INTRODUÇÃO: A hiperhomocisteinémia tem vindo a ser associada com polimorfismos genéticos das enzimas 5,10-metilenotetrahidrofolato (MTHF), cistationina β-sintetase (CBS) e dihidrofolato redutase (DHFR). São escassos os dados epidemiológicos de distribuição dos polimorfismos C677T da MTHFR, 844ins68 da CBS e deleção de 19 pares de bases do gene da DHFR em diabéticos tipo 2. Conhecer a variação polimórfica destas...
Avaliação da ingestão de micronutrientes em diabéticos tipo 2
Valente, Ana; Bicho, Manuel; Duarte, Rui; Raposo, João F.; Costa, H.S.