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Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neu...

Novo, João P.; Martins, Beatriz; Raposo, Ramon S.; Pereira, Frederico C.; Oriá, Reinaldo B; Malva, João O.; Fontes-Ribeiro, Carlos

Methylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir, MeHg bioaccumulates along the food chain until it is consumed by riverine populations. There has been much interest in the neurotoxicity of MeHg due to recent environmental disasters. Studies have also addressed the implications of long-term MeHg exposure for humans. The central nervous system is particularly susceptible t...


Methylmercury Interactions With Gut Microbiota and Potential Modulation of Neur...

Pinto, Daniel V.; Raposo, Ramon S.; Matos, Gabriella A.; Alvarez-Leite, Jacqueline I.; Malva, João O.; Oriá, Reinaldo B.

Mercury (Hg) is a well-recognized biohazard for the nervous system. Methylmercury (MeHg) is an organic methylated form of Hg, highly toxic to humans, targeting the brain, as MeHg is rapidly absorbed, and easily reaches and crosses the blood-brain barrier (Takahashi et al., 2017). Neurological symptoms may vary from acute motor and visual effects to marked behavioral and psychiatric alterations. At higher neurot...


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