2 documents found, page 1 of 1
Areca catechu - from farm to food and biomedical applications
Salehi, Bahare; Konovalov, Dmitry A.; Fru, Pascaline; Kapewangolo, Petrina; Peron, Gregorio; Ksenija, Mileski S.; Cardoso, Susana M.; Pereira, Olívia R.The family Arecaceae includes 181 genera and 2,600 species with a high diversity in physical characteristics. Areca plants, commonly palms, which are able to grow in nearly every type of habitat, prefer tropical and subtropical climates. The most studied species Areca catechu L. contains phytochemicals as phenolics and alkaloids with biological properties. The phenolics are mainly distributed in roots followed ...
A novel approach in glioblastoma multiforme drug discovery: perturbation studie...
Oliveira, Luís Carlos; Marques, Maria Paula; Caseiro, Armando José; Rapposelli, Simona; Carvalho, Ana Lúcia Batista de; Fonseca, Ana PaulaDespite impressive advances in drug discovery methods, predicting cellular response to anticancer drugs remains challenging. In glioblastoma multiforme, this fact is even marked as many promising drugs were followed by disappointment. As a result, the aim of this study is to clarify the effects of inhibition of 3-phosphoinositide-dependent protein kinase-1 (PDK1) in glioblastoma multiforme, while exploring how ...