5 documents found, page 1 of 1
shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act a...
Gonçalves, Susana A; Macedo, Diana; Raquel, Helena; Simões, Pedro D; Giorgini, Flaviano; Ramalho, José S; Barral, Duarte C; Ferreira Moita, LuísAlpha-Synuclein (aSyn) misfolding and aggregation is common in several neurodegenerative diseases, including Parkinson's disease and dementia with Lewy bodies, which are known as synucleinopathies. Accumulating evidence suggests that secretion and cell-to-cell trafficking of pathological forms of aSyn may explain the typical patterns of disease progression. However, the molecular mechanisms controlling aSyn agg...
Highly dynamic host actin reorganization around developing Plasmodium inside he...
Gomes-Santos, Carina S. S.; Itoe, Maurice A.; Afonso, Cristina; Henriques, Ricardo; Gardner, Rui; Sepúlveda, Nuno; Simões, Pedro D.; Raquel, HelenaPlasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around ...
Highly dynamic host actin reorganization around developing Plasmodium inside he...
Gomes-Santos, Carina S S; Itoe, Maurice A; Afonso, Cristina; Henriques, Ricardo; Gardner, Rui; Sepúlveda, Nuno; Simões, Pedro D; Raquel, HelenaPlasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around ...
The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lympho...
Lança, Telma; Correia, Daniel V.; Moita, Catarina F.; Raquel, Helena; Neves-Costa, Ana; Ferreira, Cristina; Ramalho, José S.; Barata, João T.On the path to successful immunotherapy of hematopoietic tumors, gamma-delta T cells offer great promise because of their human leukocyte antigen (HLA)-unrestricted targeting of a wide variety of leukemias/lymphomas. However, the molecular mechanisms underlying lymphoma recognition by gamma-delta T cells remain unclear. Here we show that the expression levels of UL16-binding protein 1 (ULBP1) determine lymphoma...
The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lympho...
Lança, Telma; Correia, Daniel V.; Moita, Catarina F.; Raquel, Helena; Neves-Costa, Ana; Ferreira, Cristina; Ramalho, José S.; Barata, João T.On the path to successful immunotherapy of hematopoietic tumors, γδ T cells offer great promise because of their human leukocyte antigen (HLA)–unrestricted targeting of a wide variety of leukemias/lymphomas. However, the molecular mechanisms underlying lymphoma recognition by γδ T cells remain unclear. Here we show that the expression levels of UL16-binding protein 1 (ULBP1) determine lymphoma susceptibility to...