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Synergistic effect of aloe vera hydrogels with imatinib for pH-responsive drug ...

Khan, Aroob Hasan; Shehzad, Adeeb; Pirela, Paola; Atalaia, Mariana; Ruivinho, Beatriz Lourenço; Rashan, Luay; Miran, Waheed; Duarte, Sofia O. D.

Imatinib (IM) efficacy as a cancer drug is limited by pharmacokinetic drug resistance developed during systemic circulation before reaching the target site.Hydrogels have attracted attention because of their characteristic physiochemical and biochemical properties, flexibility, and the ability to release drugs directly at target sites causing cancer mitigation. The current study aims at developing Aloe Vera (AV...


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