18 documents found, page 1 of 2

N-NITROSAMINAS EM MEDICAMENTOS: UM PROBLEMA ATUAL, UMA REALIDADE ANTIGA

The presence of N-nitrosamines - potentially carcinogenic compounds - is being reported for more than 50 years in pharmaceutical products. However, it only gained notorious prominence in 2018, when regulatory agencies became aware of the presence of N-nitrosodimethylamine in angiotensin II receptor antagonists, drugs that are known as sartans. It did not take long for N-nitrosamine impurities to be identified i...

Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatme...

Fluoroquinolones antimicrobials are partially excreted in natura after administration. Their occurrence was investigated in hospital raw sewage (HRS) and treated wastewater (TW) using an online solid phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method (SPE-UHPLC-MS/MS). The analytical curves ranged from 0.25 to 46 ng mL-1 and the matrix effect, assessed for marbofloxaci...

Sorption of Sulfachloropyridazine in Brazilian Soils

Sulfonamides are among the most widely employed antibacterial in veterinary medicine. Because a substantial proportion of sulfonamides are excreted unchanged as parent compounds after administration or are excreted as their metabolites through urine and feces, their presence in soils is a matter of concern. Adsorption and desorption are important processes that influence the transport, transformation and bioava...

Conyza canadensis: Green Extraction Method of Bioactive Compounds and Evaluatio...

Synthetic fungicides are a common treatment for post-harvest diseases in fruits, although demand is increasing for alternatives such as biopesticides. The aim of this work was to investigate the presence of naturally occurring antifungal compounds in Brazilian specimens of the weed Conyza canadensis. Two compounds [(4Z)-lachnophyllum lactone and (4Z,8Z)-matricaria lactone] were isolated and their antifungal act...

Design of a New Molecularly Imprinted Polymer Selective for Hydrochlorothiazide...

A molecularly imprinted polymer (MIP) for the diuretic drug hydrochlorothiazide (HCTZ) based on theoretical predictions was developed. Molecular modeling calculations were performed to study the intermolecular interactions in the pre-polymerization mixture and to select a suitable functional monomer and a porogenic solvent for the synthesis of the MIP. To confirm the results of the theoretical predictions, thre...

CONSIDERAÇÕES E IMPLICAÇÕES PRÁTICAS DO GUIA DE VALIDAÇÃO E CONTROLE DE QUALIDA...

Electric Field-Assisted Solid Phase Extraction: Study of Electrochromatographic...

Electric field-assisted solid phase extraction using syringe type cartridges (E-SPE) is a recent approach with a high capacity to obtain differential selectivity and/or recovery in comparison with conventional solid phase extraction (SPE). In this work, E-SPE was employed for the extraction of the anionic dye sunset yellow. During the washing step the electric field was evaluated with the top electrode negative...

A novel computational approach for development of highly selective fenitrothion...

The quality of molecularly imprinted recognition sites depend on the mechanisms and the extent of the functional monomer-template interactions present in the prepolymerization mixture. Thus, an understanding of the physical parameters governing these interactions is key for producing a highly selective molecularly imprinted polymer (MIP). In this paper, novel molecular modeling studies were performed to optimiz...

Ocorrência, comportamento e impactos ambientais provocados pela presença de ant...

Antimicrobials, among other veterinary drugs, are used worldwide in industry and agriculture to protect animal health and prevent economic loss. In recent years, they have been detected in various environmental compartments, including soil, surface and groundwater and have become a topic of research interest. Emphasizing this class of compounds, this review presents the different pathways which veterinary drugs...

Contaminação de produtos de higiene e cosméticos por n-nitrosaminas

N-nitrosamines are carcinogenic compounds that have been found during the last three decades in a variety of consumer products, including cosmetic and personal care products, and their raw materials. These compounds are formed from amine precursors and nitrosating agents present in the formulations. This paper reviews the formation and occurrence of N-nitrosamines in cosmetic products, as well as presents consi...