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Enhanced sweet taste perception in obesity: joint analysis of gustatory data fr...

Ribeiro, Gabriela; Torres, Sandra; Fernandes, Ana B.; Camacho, Marta; Branco, Teresa L.; Martins, Sandra S.; Raimundo, Armando; Oliveira-Maia, Albino J.

Introduction: While sweet taste perception is a potential determinant of feeding behavior in obesity, the supporting evidence is inconsistent and is typically associated with methodological limitations. Notably, possible associations between sweet taste perception and measures of food reward remain undetermined. Materials and methods: We conducted a cross-sectional analysis comparing 246 individuals with severe...


Reward-related gustatory and psychometric predictors of weight loss following b...

Ribeiro, Gabriela; Camacho, Marta; Fernandes, Ana B.; Cotovio, Gonçalo; Torres, Sandra; Oliveira-Maia, Albino J.

Background: Reward sensitivity has been proposed as a potential mediator of outcomes for bariatric surgery. Objectives: We aimed to determine whether gustatory and psychometric measures of reward-related feeding are predictors of bariatric-induced weight loss. Methods: A multicenter longitudinal cohort study was conducted in patients scheduled for bariatric surgery (surgical group), assessed at baseline and 2 f...


Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neu...

Fernandes, Ana B.; Alves da Silva, Joaquim; Almeida, Joana; Cui, Guohong; Gerfen, Charles R.; Costa, Rui M.; Oliveira-Maia, Albino J.

Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors. Here we report a causal connection between postingestive sucrose sensing and vagus-mediated dopamine neuron activity in the ventral tegmental area (VTA), supporting food seeking. The activity of VTA dopamine neurons increases significantly after a...

Date: 2020   |   Origin: Champalimaud Foundation

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