2 documents found, page 1 of 1
The maintenance of centriole appendages and motile cilia basal body anchoring r...
Carmona, Bruno; Camelo, Carolina; Mehraz, Manon; Lemullois, Michel; Faria, Mariana Lince; Coyaud, Étienne; Marinho, H. Susana; Gonçalves, JoãoCentrosomes are organelles consisting of two structurally and functionally distinct centrioles, with the mother centriole having complex distal (DA) and subdistal appendages (SDA). Despite their importance, how appendages are assembled and maintained remains unclear. This study investigated human TBCCD1, a centrosomal protein essential for centrosome positioning, to uncover its localization and role at centriol...
Unraveling the role of TBCCD1 protein on cell size control: the regulation of c...
Camelo, Carolina; Peneda, Catarina; Coyaud, Étienne; Raught, Brian; Câmara, Ana I.; Carmona, Bruno; Pinto, Francisco; Narinho, H. Susana; Soares, HelenaDuring their lifetime most cells maintain their size. There is increasing evidence showing that this process may be dynamic and that cells can adapt their size in response to external signals and changes in the environment [1], which strongly suggests that cell size is regulated. Both Hippo and IGF/PI3K/AKT/mTORC1 pathways have been described as being involved in cell size/growth control [1]. Interestingly, the...