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Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, ne...
Vanden Eynde, JJ; Mangoni, AA; Rautio, J; Leprince, J; Azuma, YT; García-Sosa, AT; Hulme, C; Jampilek, J; Karaman, R; Li, W; Gomes, PAC
Date: 2020
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Origin: Repositório Aberto da Universidade do Porto
Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, Ne...
Mangoni, AA; Eynde, JJV; Jampilek, J; Hadjipavlou-Litina, D; Liu, H; Reynisson, J; Sousa, ME; Gomes, PAC; Prokai-Tatrai, K; Tuccinardi, T; Sabatier, JM
Date: 2019
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Origin: Repositório Aberto da Universidade do Porto
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, ne...
Mangoni, AA; Guillou, C; Eynde, JJV; Hulme, C; Jampilek, J; Li, W; Prokai-Tatrai, K; Rautio, J; Collina, S; Tuccinardi, T; Sousa, ME; Sabatier, JM
Date: 2019
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Origin: Repositório Aberto da Universidade do Porto
Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl e...
Mendes, E; Furtado, T; Neres, J; Iley, J; Jarvinen, T; Rautio, J; Moreira, RAminocarbonyloxymethyl esters 3 based on (S)-amino acid carriers were synthesised and evaluated as potential prodrugs of carboxylic acid agents. In addition, the compounds were evaluated as topical prodrugs with the aim of improving the dermal delivery of two non-steroidal anti-inflammatory agents: naproxen and flufenamic acid. The lipophilicities of these compounds were determined and their hydrolyses in aqueo...
Date: 2002
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Origin: Repositório da Universidade de Lisboa