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Body composition analysis in metastatic non-small-cell lung cancer: depicting s...

Mendes, José Leão; Ferreira, Rita Quaresma; Mata, Inês; Barreira, João Vasco; Rodrigues, Ysel Chiara; Dias, David Silva; Capelas, Manuel Luís

Background/Objectives: Sarcopenia is an emergent prognostic biomarker in clinical oncology. Albeit increasingly defined through skeletal muscle index (SMI) thresholding, the literature cut-offs fail to discern heterogeneous baseline muscularity across populations. This study assesses the prognostic impact of using cohort-specific SMI thresholds in a Portuguese metastatic non-small-cell lung cancer (mNSCLC) coho...


Body composition analysis in metastatic non-small-cell lung cancer: depicting s...

Mendes, José Leão; Ferreira, Rita Quaresma; Mata, Inês; Barreira, João Vasco; Rodrigues, Ysel Chiara; Dias, David Silva; Capelas, Manuel; Mäkitie, Antti

Background/Objectives: Sarcopenia is an emergent prognostic biomarker in clinical oncology. Albeit increasingly defined through skeletal muscle index (SMI) thresholding, literature cut-offs fail to discern heterogeneous baseline muscularity across populations. This study assesses the prognostic impact of using cohort-specific SMI thresholds in a Portuguese metastatic non-small-cell lung cancer (mNSCLC) cohort. ...


Body Composition Analysis in Metastatic Non-Small-Cell Lung Cancer: Depicting S...

Leão Mendes, José; Ferreira, Rita Quaresma; Mata, Inês; Vasco Barreira, João; Rodrigues, Ysel Chiara; Silva Dias, David; Capelas, Manuel Luís

Sarcopenia is an emergent prognostic biomarker in clinical oncology. Albeit increasingly defined through skeletal muscle index (SMI) thresholding, the literature cut-offs fail to discern heterogeneous baseline muscularity across populations. This study assesses the prognostic impact of using cohort-specific SMI thresholds in a Portuguese metastatic non-small-cell lung cancer (mNSCLC) cohort. : Retrospective stu...


A systematic review of vitamin D supplementation in oncology: chance of science...

Afonso, Marta Lourenço; Capelas, Manuel Luís; Pimenta, Nuno M.; Santos, Teresa; Mäkitie, Antti; Ganhão-Arranhado, Susana; Trabulo, Carolina

Background: Vitamin D (VD) supplementation has increased considerably in the last decade, whether for the prevention or treatment of numerous diseases, including bone, cardiovascular, endocrine, neurologic, psychological, respiratory, infectious, or oncological. The primary objective of this scoping review was to examine and synthesize the scientific evidence on the role of VD in all-type cancer patients underg...


The science of micronutrients in clinical practice – Report on the ESPEN symposium

Berger, Mette M.; Amrein, Karin; Barazzoni, Rocco; Bindels, Laure; Bretón, Irene; Calder, Philip C.; Cappa, Stefano; Cuerda, Cristina

Background & aims: The European Society for Clinical Nutrition and Metabolism published its first clinical guidelines for use of micronutrients (MNs) in 2022. A two-day web symposium was organized in November 2022 discussing how to apply the guidelines in clinical practice. The present paper reports the main findings of this symposium. Methods: Current evidence was discussed, the first day being devoted to clar...


Nutritional care in older adults: are we doing everything? An expert opinion re...

Sanchez-Garcia, Elisabet; Cruz-Jentoft, Alfonso J.; Ravasco, Paula; Suominen, Merja; Pitkälä, Kaisu

Malnutrition is a prevalent, yet often underdiagnosed and undertreated, condition in older adults. It is characterized by weight loss and/or reduced muscle mass due to diminished caloric intake, inflammation, and/or disease burden. In return, malnutrition can lead to diminished skeletal muscle functionality and disability, among others. Malnutrition plays a crucial role in the pathogenesis of two prevalent geri...


The impact of pre-, pro- and synbiotics supplementation in colorectal cancer tr...

Moreira, Mariana Melo; Carriço, Marta; Capelas, Manuel Luís; Pimenta, Nuno; Santos, Teresa; Ganhao-Arranhado, Susana; Mäkitie, Antti; Ravasco, Paula

Introduction: The effectiveness of the supplementation of prebiotics, probiotics and synbiotics as a therapeutic approach in colorectal cancer (CRC) remains unclear. The aim of this systematic review is to critically examine the current scientific evidence on the impact of modulating the microbiota, through the use of prebiotics, probiotics and synbiotics, in patients diagnosed with CRC undergoing treatment, to...


Nutritional care in older adults : are we doing everything? An expert opinion r...

Sanchez-Garcia, Elisabet; Cruz-Jentoft, Alfonso J.; Ravasco, Paula; Suominen, Merja; Pitkäläd, Kaisu

Malnutrition is a prevalent, yet often underdiagnosed and undertreated, condition in older adults. It is characterized by weight loss and/or reduced muscle mass due to diminished caloric intake, inflammation, and/or disease burden. In return, malnutrition can lead to diminished skeletal muscle functionality and disability, among others. Malnutrition plays a crucial role in the pathogenesis of two prevalent geri...


Corrigendum: Impact of body composition on prognosis and dose-limiting toxiciti...

Dias, David da Silva; Machado, Mafalda; Trabulo, Carolina; Gosálbez, Beatriz; Ravasco, Paula

In the published article, there was an error regarding the affiliation for David da Silva Dias. As well as having affiliations 1 and 2, they should also be affiliated to “Faculdade de Ciências da Saúde da Universidade da Beira Interior, Covilhã, Portugal.” The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been ...


Oncology-led early identification of nutritional risk: a pragmatic, evidence-ba...

Muscaritoli, Maurizio; Bar-Sela, Gil; Battisti, Nicolo Matteo Luca; Belev, Borislav; Contreras-Martínez, Jorge; Cortesi, Enrico; de Brito-Ashurst, Ione

Nutritional issues, including malnutrition, low muscle mass, sarcopenia (i.e., low muscle mass and strength), and cachexia (i.e., weight loss characterized by a continuous decline in skeletal muscle mass, with or without fat loss), are commonly experienced by patients with cancer at all stages of disease. Cancer cachexia may be associated with poor nutritional status and can compromise a patient’s ability to to...


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