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Phase II validation study of the rK39 ELISA prototype for the diagnosis of cani...
Medeiros,Fernanda Alvarenga Cardoso; Souza Filho,Job Alves de; Barbosa,José Ronaldo; Donato,Lucas Edel; Figueiredo,Fabiano BorgesAbstract: Dogs are the main reservoirs in the domestic transmission cycle of visceral leishmaniasis, and the diagnosis is essential for the effectiveness of the control measures recommended by the Brazilian Ministry of Health. We assessed the diagnostic performance of the ELISA-Vetlisa/BIOCLIN prototype with serum samples from 200 dogs, in triplicate, including symptomatic, oligosymptomatic, asymptomatic, and h...
Visceral leishmaniasis lethality in Brazil: an exploratory analysis of associat...
Donato,Lucas Edel; Freitas,Lúcia Rolim Santana de; Duarte,Elisabeth Carmen; Romero,Gustavo Adolfo SierraAbstract INTRODUCTION: It is believed that delays in diagnosis and treatment of Visceral Leishmaniasis (VL) contribute significantly to the burden of VL lethality in Brazil. METHODS: This study included several parts: a descriptive cross-sectional study of the individual characteristics of deaths from disease; a descriptive ecological study of the spatial distribution of deaths from disease; and an ecological a...