3 documents found, page 1 of 1
Liposomes loaded with the pneumococcal endolysin MSlys: From in vitro character...
Silva, Maria Daniela; Paris, Juan Luis; Ray, Kaelin; Gama, F. M.; Silva, Bruno F. B.; Remenshneider, A. K.; Sillankorva, SannaIntroduction: The increasing antibiotic resistance triggered interest in novel antimicrobials as well as delivery systems that allow a topical and targeted delivery. However, biological barriers, such as the skin or the tympanic membrane (TM), may hinder the success of the therapy. Drug permeation has been extensively studied in the context of transdermal delivery, but only recently started to be explored for t...
Ex vivo transtympanic permeation of the liposome encapsulated S. pneumoniae end...
Silva, Maria Daniela; Ray, Kaelin; Gama, F. M.; Remenschneider, Aaron K.; Sillankorva, SannaAn increase in bacterial resistance to systemic antibiotics has sparked interest into alternative antimicrobial compounds as well as methods for effective local, non-invasive drug delivery. Topical treatments, however, may be hindered by the presence of biological barriers, such as the tympanic membrane in the case of otitis media. Herein, the transtympanic permeation ability of liposomes loaded with the pneumo...
Exploring endolysin-loaded liposomes for a transtympanic treatment of S. pneumo...
Silva, Maria Daniela; Paris, Juan Luis; Ray, Kaelin; Gama, F. M.; Silva, Bruno F. B.; Remenshneider, A. K.; Sillankorva, SannaOtitis media, the main reason for which antibiotics are prescribed in childhood, is often caused by Streptococcus pneumoniae. The exogenous use of recombinantly produced endolysins, peptidoglycan hydrolases encoded by bacteriophages at the end of their lytic cycle, have been shown to be very effective against this pathogen. To increase bioavailability, and consequently reduce the probability of a recurrent or c...