5 documents found, page 1 of 1
Liposome-based diagnostic and therapeutic applications for pancreatic cancer
Raza, Faisal; Evans, Lauren; Motallebi, Mahzad; Zafar, Hajra; Pereira-Silva, Miguel; Saleem, Kalsoom; Peixoto, Diana; Rahdar, Abbas; Sharifi, EsmaeelPancreatic cancer is one of the harshest and most challenging cancers to treat, often labeled as incurable. Chemotherapy continues to be the most popular treatment yet yields a very poor prognosis. The main barriers such as inefficient drug penetration and drug resistance, have led to the development of drug car- rier systems. The benefits, ease of fabrication and modification of liposomes render them as ideal ...
Cyclodextrin-based dermatological formulations: Dermopharmaceutical and cosmeti...
Ferreira, Laura; Mascarenhas-Melo, Filipa; Rabaça, Sofia; Mathur, Ankita; Sharma, Ankur; Giram, Prabhanjan S.; Pawar, Kiran D.; Rahdar, AbbasThe progress in new delivery systems for active ingredients has boosted the dermopharmaceutical and cosmetic fields by allowing formulations to display enhanced skin permeation capabilities. Cyclodextrins (CDs) are cyclic oligosaccharides able to form host-guest inclusion complexes with guest active molecules, resulting in improved physicochemical properties of such molecules. The incorporation of CDs in dermop...
Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidi...
Altaf, Reem; Nadeem, Humaira; Ilyas, Umair; Iqbal, Jamshed; Paracha, Rehan Zafar; Zafar, Hajra; Paiva-Santos, Ana Cláudia; Sulaiman, MuhammadThe diverse pharmacological role of dihydropyrimidinone scaffold has made it to be an interesting drug target. Because of the high incidence and mortality rate of breast cancer, there is a dire need of discovering new pharmacotherapeutic agents in managing this disease. A series of twenty-two derivatives of 6-(chloromethyl)-4-(4-hydroxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (3a-3k) and ethyl 6...
Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy
Aktar, Nasrin; Yueting, Chen; Abbas, Muhammad; Zafar, Hajra; Paiva-Santos, Ana Cláudia; Zhang, Qin; Chen, Tingting; Ahmed, Moudud; Raza, FaisalTumor immune escape has emerged as the most significant barrier to cancer therapy. A thorough understanding of tumor immune escape therapy mechanisms is critical for further improving clinical treatment strategies. Currently, research indicates that combining several immunotherapies can boost antitumor efficacy and encourage T cells to play a more active part in the immune assault. To generate a more substantia...
pH-Sensitive Peptide Hydrogels as a Combination Drug Delivery System for Cancer...
Liu, Yuanfen; Ran, Yingchun; Ge, Yu; Raza, Faisal; Li, Shasha; Zafar, Hajra; Wu, Yiqun; Paiva-Santos, Ana Cláudia; Yu, Chenyang; Sun, Meng; Zhu, YingConventional antitumor chemotherapeutics generally have shortcomings in terms of dissolubility, selectivity and drug action time, and it has been difficult to achieve high antitumor efficacy with single-drug therapy. At present, combination therapy with two or more drugs is widely used in the treatment of cancer, but a shortcoming is that the drugs do not reach the target at the same time, resulting in a reduct...