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Increased ATP release and CD73-mediated adenosine A2A receptor activation media...
Augusto, Elisabete de Oliveira; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, MarcoExtracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR). Convulsive activity leads to increased ATP release, with the resulting morphological alterations being eliminated by A2AR blockade. However, it is not known i...
Date: 2021
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Origin: Estudo Geral - Universidade de Coimbra