26 documents found, page 1 of 3
HBM4EU - Deliverable Report D 5.5: Human biomonitoring in risk assessment: 2nd ...
Santonen, Tiina; Mahiout, Selma; Bessems, J.; Buekers, J.; Baken, K.; Schoeters, G.; Woutersen, M.; Vermeire, T.; Bil, W.; Ougier, E.; Rousselle, C.The aim of this work was to exemplify the inclusion of human biomonitoring (HBM) data in risk assessment (RA) and health impact assessment (HIA) strategies. RA was performed for six compound groups on HBM4EU’s first list of priority substances: anilines, cadmium/chromium, flame retardants, PAHs, PFAS and phthalates. In addition, burden of disease (BoD) calculations were made for cadmium. The general approach us...
Fatty Liver and Autoimmune Hepatitis: Two Forms of Liver Involvement in Lipodys...
Ribeiro, A.; Brandão, J.; Cleto, Esmeralda; Santos, M.; Borges, T.; Santos Silva, E.Introduction: Lipodystrophies are a heterogeneous group of rare diseases (genetic or acquired) characterized by a partial or generalized deficit of adipose tissue, resulting in less energy storage capacity. They are associated with severe endocrine-metabolic complications with significant morbidity and mortality. In the pathogenesis of the acquired forms, immunological disorders may be involved. Case 1: A 13-ye...
Prenatal Diagnosis and Management of a Fetal Goiter Hypothyroidism due to Dysho...
Figueiredo, C.; Falcão, I.; Vilaverde, J.; Freitas, J.; Oliveira, M.; Godinho, C.; Dores, J.; Rodrigues, M.; Carvalho, C.; Borges, T.Fetal goiter is a rare disorder not expected to be found during a healthy woman's pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks' gestation of a healthy primigravida. Magnetic resonance was suggestive of goiter causing airway deviation without p...
Improving risk assessment of chemicals by the use of human biomonitoring: HBM4E...
Santonen, T.; Alvito, P.; Bessems, J.; Borges, T.; Brunet, D.; Buekers, J.; Cornelis, C.; van Engelen, J.; Gonzalez Caballero, M. C.; Humar-Juric, T.The default approach in the risk assessment (RA) of chemicals is to assess external exposure by combining different sources and routes of exposure. This kind of approach contains various uncertainties and may overestimate exposure, since conservative estimates are needed due to the limited data on, for example, the absorption of the chemical and interspecies and intraspecies differences. Human biomonitoring (HB...
Human biomonitoring in risk assessment: analysis of the current practice and 1s...
Santonen, T.; Heinälä, M.; Bessems, J.; Buekers, J.; Cornelis, C.; Vermeire, T.; Woutersen, M.; van Engelen, J.; Borges, T.; Rousselle, C.; Ougier, E.In chemicals risk assessment frameworks, the default approach is to assess external intake from different sources of exposure and via different routes of exposure. They are often assessed separately. This approach includes various uncertainties and often overestimates the real uptake since default, conservative estimates are used e.g. for the absorption of the chemical. At the same time, actual (real life) expo...
Improving risk assessment of chemicals by the use of human biomonitoring - HBM4...
Santonen, T.; Alvito, Paula; Bessems, J.; Borges, T.; Brunet, D.; Buekers, J.; Cornelis, C.; van Engelen, J.; Gonzalez Caballero, M.C.; Humar-Juric, T.The default approach in the risk assessment (RA) of chemicals is to assess external exposure by combining different sources and routes of exposure. This kind of approach contains various uncertainties and may overestimate exposure, since conservative estimates are needed due to the limited data on, for example, the absorption of the chemical and interspecies and intraspecies differences. Human biomonitoring (HB...
Results of a round-robin exercise on read-across
Benfenatia, E.; Bellia, M.; Borges, T.; Casimiro, E.; Cester, J.; Fernandez, A.; et alA round-robin exercise was conducted within the CALEIDOSLIFE project. The participants were invited to assess the hazard posed by a substance, applying in silico methods and read-across approaches. The exercise was based on three endpoints: mutagenicity, bioconcentration factor and fish acute toxicity. Nine chemicals were assigned for each endpoint and the participants were invited to complete a specific questi...
Investigação e avaliação de risco: contributo do projeto MYCOMIX
Alvito, Paula; Martins, Carla; Assunção, Ricardo; Silva, M.J.; Louro, H.; Borges, T.; Loureiro, S.; Leal, S.; Dupond, D.; Seljak, B.Sumário: 1. Misturas de micotoxinas nos alimentos – uma realidade 2. Avaliação de risco – alteração de paradigma 3. Desafios associados à avaliação de risco de misturas de micotoxinas em alimentos 4. Projeto MYCOMIX – um caso estudo
Towards a nanospecific approach for risk assessment.
Dekkers, S.; Oomen, A.G.; Bleeker, E.A.; Vandebriel, RJ..; Micheletti, C.; Cabellos, J.; Janer, G.; Fuentes, N.; Vázquez-Campos, S.; Borges, T.In the current paper, a new strategy for risk assessment of nanomaterials is described, which builds upon previous project outcomes and is developed within the FP7 NANoREG project. NANoREG has the aim to develop, for the long term, new testing strategies adapted to a high number of nanomaterials where many factors can affect their environmental and health impact. In the proposed risk assessment strategy, approa...
Interview anxiety narrative validation for a virtual reality-based study
Borges, T.; Ramos, S.; Vilar, E.; Noriega, P.; Rebelo, F.When conducting a Virtual Reality-based study one important feature that needs to be assured is valid is the narrative context. Our objective was to validate a job interview anxiety provoking narrative. One experiment with a between-subject design was conducted. Participants were instructed to read a job interview-context narrative and then self-report the level of anxiety experienced. Results indicated that th...