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Decoding Klebsiella pneumoniae in Poultry Chain: Unveiling Genetic Landscape, A...

Mourão, J.; Magalhães, Mafalda; Ribeiro-Almeida, M.; Rebelo, A; Novais, Carla; Peixe, Luísa; Novais, Â.; Antunes, Patrícia

<jats:title>Abstract</jats:title><jats:p>The rise of antibiotic resistance in the food chain is influenced by the use of antimicrobial agents, such as antibiotics, metals, and biocides, throughout the entire farm-to-fork continuum. Besides, non-clinical reservoirs potentially contribute to the transmission of critical pathogens such as multidrug-resistant (MDR)<jats:italic>Klebsiella pneumoniae</jats:italic>. H...


Unraveling the Role of Metals and Organic Acids in Bacterial Antimicrobial Resi...

Rebelo, A; Agostinho Almeida; Peixe, L.; Antunes, Patrícia; Novais, C.

Antimicrobial resistance (AMR) has a significant impact on human, animal, and environmental health, being spread in diverse settings. Antibiotic misuse and overuse in the food chain are widely recognized as primary drivers of antibiotic-resistant bacteria. However, other antimicrobials, such as metals and organic acids, commonly present in agri-food environments (e.g., in feed, biocides, or as long-term polluta...


Unraveling the Role of Metals and Organic Acids towards Bacterial Antimicrobial...

Rebelo, A; Almeida, A; Peixe, L.; Antunes, Patrícia; Novais, Carla

<jats:p>Antimicrobial resistance (AMR) has a significant global impact on human, animal, and environmental health. Misuse and overuse of antibiotics in clinical and animal production settings are the main drivers behind the emergence of antimicrobial resistant bacteria. However, other compounds with antimicrobial activity may also contribute to this global public health problem. The aim of this comprehensive re...


Exploring Peracetic Acid and Acidic pH Tolerance of Antibiotic Resistant Non-ty...

Rebelo, A; Duarte, B; R. Freitas, A; Peixe, L.; Antunes, Patrícia; Novais, Carla

<jats:p>Acid stress poses a common challenge for bacteria in diverse environments by the presence of inorganic (e.g., mammals stomach) or organic acids (e.g., feed additives; acid-based disinfectants). Limited knowledge exists regarding acid-tolerant strains of specific serotypes, clonal lineages, or sources in human/animal pathogens, namely non-typhoidal Salmonella enterica (NTS) and Enterococcus faecium (Efm)...


From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and C...

Mourão, J; Ribeiro-Almeida, M; Novais, Carla; Magalhães, M.; Rebelo, A; Ribeiro, S; Peixe, L.; Novais, Â; Antunes, Patrícia

<jats:p>The spread of bacteria resistant to last-resort antibiotics such as colistin throughout the food chain is a serious concern for public health. The poultry sector has responded by restricting colistin use and exploring alternative trace metals/copper feed supplements.</jats:p>


Uncovering the effects of copper feed supplementation on the selection of coppe...

Rebelo, A; Duarte, B; Freitas, AR; Agostinho Almeida; Azevedo, R; Pinto, E; Peixe, L.; Antunes, Patrícia; Novais, Carla


Diversity of metal and antibiotic resistance genes in Enterococcus spp. from th...

Rebelo, A; Mourao, J; Freitas, AR; Duarte, B; Silveira, E; Sanchez Valenzuela, A; Agostinho Almeida; Baquero, F; Coque, TM; Peixe, L.; Antunes, Patrícia

Arsenic (As), mercury (Hg), and copper (Cu) are among the major historical and contemporary metal pollutants linked to global anthropogenic activities. Enterococcus have been considered indicators of fecal pollution and antibiotic resistance for years, but its largely underexplored metallome precludes understanding their role as metal pollution bioindicators as well. Our goal was to determine the occurrence, di...


MicroMundo@UPorto: an experimental microbiology project fostering student's ant...

Antunes, Patrícia; Novais, C.; Novais, A; Grosso, F; Ribeiro, TG; Mourao, J; Perovic, SU; Rebelo, A; Ksiezarek, M; Freitas, AR; Peixe, L.

Antimicrobial resistance (AMR) is a global societal challenge requiring the contribution of professionals along with general community citizens for their containment. Portugal is one of the European countries where a lack of knowledge on the correct use of antimicrobials and AMR problematic is preeminent. Moreover, youth demotivation to pursue science careers is emerging. To address these problems an innovative...


Tolerance to arsenic contaminant among multidrug-resistant and copper-tolerant ...

Mourao, J; Rebelo, A; Ribeiro, S; Peixe, L.; Novais, Carla; Antunes, Patrícia

Emergence and expansion of frequent multidrug-resistant (MDR) major Salmonella clones/serotypes has been a significant threat in the last years. Metal compounds, such as copper, commonly used in animal-production settings, have been pointed out as possible contributors for the selection of such strains/clones. However, the scarcity of studies limits our understanding of the impact of other metal environmental c...


Atypical Non-H2S-Producing Monophasic Salmonella Typhimurium ST3478 Strains fro...

Mourao, J; Rebelo, A; Ribeiro, S; Peixe, L.; Novais, Carla; Antunes, Patrícia

Poultry products are still an important cause of Salmonella infections worldwide, with an increasingly reported expansion of less-frequent serotypes or atypical strains that are frequently multidrug-resistant. Nevertheless, the ability of Salmonella to survive antimicrobials promoted in the context of antibiotic reducing/replacing and farming rethinking (e.g., organic acids and copper in feed/biocides) has been...


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