4 documents found, page 1 of 1
Distribution of alien tetrapods in the Iberian Peninsula
Ascensão, F; D'Amico, M; Martins, R; Rebelo, R; Barbosa, M; Bencatel; Santos, Sara Maria; Mira, A; Mathias, ML; Tiago, PWe present a dataset that assembles occurrence records of alien tetrapods (amphibians, reptiles, birds and mammals) in the Iberian Peninsula, a coherent biogeographically unit where introductions of alien species have occurred for millennia. These data have important potential applications for ecological research and management, including the assessment of invasion risks, formulation of preventive and managemen...
Synthesis of novel methyl 3-(Hetero)arylthieno[3,2-b]pyridine-2-carboxylates an...
Silva, BR; Rebelo, R; Rodrigues, JM; Xavier, CPR; Vasconcelos, MH; Queiroz, MJRPA series of novel functionalized methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates 2a–2h were synthesized by C-C Pd-catalyzed Suzuki-Miyaura cross-coupling of methyl 3-bromothie-no[3,2-b]pyridine-2-carboxylate with (hetero)aryl pinacol boranes, trifluoro potassium boronate salts or boronic acids. Their antitumoral potential was evaluated in two triple negative breast cancer (TNBC) cell lines—MDA-MB-231 ...
Drug repurposing opportunities in pancreatic ductal adenocarcinoma
Rebelo, R; Polónia, B; Santos, LL; Vasconcelos, MH; Xavier, CPRPancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest tumors worldwide. The diagnosis is often possible only in the latter stages of the disease, with patients already presenting an advanced or metastatic tumor. It is also one of the cancers with poorest prognosis, presenting a five-year survival rate of around 5%. Treatment of PDAC is still a major challenge, with cytotoxic chemotherapy re...
COVID-19 e as pessoas em situação de sem-abrigo: Ninguém pode ser deixado para ...
Aguiar, A; Meireles, P; Rebelo, R; Barros, HA infeção pode ocorrer em qualquer idade, mas são as pessoas mais velhas ou com doenças crónicas que estão em maior risco de complicações graves e morte devido à doença. O SARS-CoV-2 pode-se transmitir de pessoa para pessoa por gotículas respiratórias, contacto direto com secreções infetadas e por aerossóis gerados por procedimentos terapêuticos, não havendo ainda evidência clara de transmissão por via aérea. A...